Matches in SemOpenAlex for { <https://semopenalex.org/work/W2259743896> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2259743896 endingPage "C1044" @default.
- W2259743896 startingPage "C1033" @default.
- W2259743896 abstract "Cl- transport was studied in human nasal epithelium, a predominantly Na+-absorbing proximal airway epithelium. Intracellular Cl- activity (aClc) and the electrical potentials across the apical (Va) and basolateral (Vb) membranes were measured with double-barreled, Cl- -selective microelectrodes to characterize the driving forces for Cl- flow across each membrane. Under control conditions (bilateral Krebs-bicarbonate Ringer), Va was -26.1 +/- 1.2 mV, Vb was -36.2 +/- 1.2 mV, and aCL(c) was 42.7 +/- 2.0 mM (n = 34), indicating that Cl- is near electrochemical equilibrium across the apical membrane but significantly above equilibrium across the basolateral membrane. Reduction of luminal [Cl-] from 120 to 3 mM reduced aClc from 42.7 +/- 4.0 to 27.0 +/- 3.5 mM, depolarized Va, and increased fractional apical membrane resistance (fRa) and transepithelial resistance (Rt). Serosal bumetanide reduced aClc by 10 mM without affecting electrical parameters. Reduction of serosal [Cl-] from 120 to 3 mM resulted in a rapid decrease in Vb, a decrease in fRa and an increase in Rt. Also, serosal [Cl-] reduction led to a slow decrease in aClc rom 45.5 +/- 2.5 to 31.1 +/- 4.2 mM) that could be inhibited by bumetanide. The data are consistent with the following conclusions: 1) Cl- is transported across the apical membrane through a conductive pathway; and 2) Cl- is translocated across the basolateral membrane by an electrically silent bumetanide-sensitive cotransport system and by a minor conductive path." @default.
- W2259743896 created "2016-06-24" @default.
- W2259743896 creator A5001166056 @default.
- W2259743896 creator A5005672335 @default.
- W2259743896 creator A5074871331 @default.
- W2259743896 date "1989-05-01" @default.
- W2259743896 modified "2023-10-16" @default.
- W2259743896 title "Intracellular Cl- activity and cellular Cl- pathways in cultured human airway epithelium" @default.
- W2259743896 cites W1963541868 @default.
- W2259743896 cites W2032013293 @default.
- W2259743896 cites W2066318082 @default.
- W2259743896 cites W2126458759 @default.
- W2259743896 cites W2145970171 @default.
- W2259743896 doi "https://doi.org/10.1152/ajpcell.1989.256.5.c1033" @default.
- W2259743896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2719093" @default.
- W2259743896 hasPublicationYear "1989" @default.
- W2259743896 type Work @default.
- W2259743896 sameAs 2259743896 @default.
- W2259743896 citedByCount "139" @default.
- W2259743896 countsByYear W22597438962012 @default.
- W2259743896 countsByYear W22597438962013 @default.
- W2259743896 countsByYear W22597438962014 @default.
- W2259743896 countsByYear W22597438962015 @default.
- W2259743896 countsByYear W22597438962016 @default.
- W2259743896 countsByYear W22597438962017 @default.
- W2259743896 countsByYear W22597438962019 @default.
- W2259743896 countsByYear W22597438962020 @default.
- W2259743896 countsByYear W22597438962022 @default.
- W2259743896 crossrefType "journal-article" @default.
- W2259743896 hasAuthorship W2259743896A5001166056 @default.
- W2259743896 hasAuthorship W2259743896A5005672335 @default.
- W2259743896 hasAuthorship W2259743896A5074871331 @default.
- W2259743896 hasConcept C12554922 @default.
- W2259743896 hasConcept C178790620 @default.
- W2259743896 hasConcept C181911157 @default.
- W2259743896 hasConcept C185592680 @default.
- W2259743896 hasConcept C188053792 @default.
- W2259743896 hasConcept C2778212192 @default.
- W2259743896 hasConcept C2781112554 @default.
- W2259743896 hasConcept C28938303 @default.
- W2259743896 hasConcept C3018436504 @default.
- W2259743896 hasConcept C39587587 @default.
- W2259743896 hasConcept C41625074 @default.
- W2259743896 hasConcept C529295009 @default.
- W2259743896 hasConcept C537181965 @default.
- W2259743896 hasConcept C54355233 @default.
- W2259743896 hasConcept C55493867 @default.
- W2259743896 hasConcept C79879829 @default.
- W2259743896 hasConcept C86803240 @default.
- W2259743896 hasConcept C87568996 @default.
- W2259743896 hasConcept C99975950 @default.
- W2259743896 hasConceptScore W2259743896C12554922 @default.
- W2259743896 hasConceptScore W2259743896C178790620 @default.
- W2259743896 hasConceptScore W2259743896C181911157 @default.
- W2259743896 hasConceptScore W2259743896C185592680 @default.
- W2259743896 hasConceptScore W2259743896C188053792 @default.
- W2259743896 hasConceptScore W2259743896C2778212192 @default.
- W2259743896 hasConceptScore W2259743896C2781112554 @default.
- W2259743896 hasConceptScore W2259743896C28938303 @default.
- W2259743896 hasConceptScore W2259743896C3018436504 @default.
- W2259743896 hasConceptScore W2259743896C39587587 @default.
- W2259743896 hasConceptScore W2259743896C41625074 @default.
- W2259743896 hasConceptScore W2259743896C529295009 @default.
- W2259743896 hasConceptScore W2259743896C537181965 @default.
- W2259743896 hasConceptScore W2259743896C54355233 @default.
- W2259743896 hasConceptScore W2259743896C55493867 @default.
- W2259743896 hasConceptScore W2259743896C79879829 @default.
- W2259743896 hasConceptScore W2259743896C86803240 @default.
- W2259743896 hasConceptScore W2259743896C87568996 @default.
- W2259743896 hasConceptScore W2259743896C99975950 @default.
- W2259743896 hasIssue "5" @default.
- W2259743896 hasLocation W22597438961 @default.
- W2259743896 hasLocation W22597438962 @default.
- W2259743896 hasOpenAccess W2259743896 @default.
- W2259743896 hasPrimaryLocation W22597438961 @default.
- W2259743896 hasRelatedWork W1962798628 @default.
- W2259743896 hasRelatedWork W2037099586 @default.
- W2259743896 hasRelatedWork W2051050551 @default.
- W2259743896 hasRelatedWork W2080028500 @default.
- W2259743896 hasRelatedWork W2088249030 @default.
- W2259743896 hasRelatedWork W2132857448 @default.
- W2259743896 hasRelatedWork W2259743896 @default.
- W2259743896 hasRelatedWork W2406347488 @default.
- W2259743896 hasRelatedWork W2412182362 @default.
- W2259743896 hasRelatedWork W2413795831 @default.
- W2259743896 hasVolume "256" @default.
- W2259743896 isParatext "false" @default.
- W2259743896 isRetracted "false" @default.
- W2259743896 magId "2259743896" @default.
- W2259743896 workType "article" @default.