FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2259816268> ?p ?o ?g. }

• W2259816268 endingPage "412" @default.
• W2259816268 startingPage "408" @default.
• W2259816268 abstract "Phosphoinositides are a minor class of short-lived membrane phospholipids that serve crucial functions in cell physiology ranging from cell signalling and motility to their role as signposts of compartmental membrane identity. Phosphoinositide 4-phosphates such as phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) are concentrated at the plasma membrane, on secretory organelles, and on lysosomes, whereas phosphoinositide 3-phosphates, most notably phosphatidylinositol 3-phosphate (PI(3)P), are a hallmark of the endosomal system. Directional membrane traffic between endosomal and secretory compartments, although inherently complex, therefore requires regulated phosphoinositide conversion. The molecular mechanism underlying this conversion of phosphoinositide identity during cargo exit from endosomes by exocytosis is unknown. Here we report that surface delivery of endosomal cargo requires hydrolysis of PI(3)P by the phosphatidylinositol 3-phosphatase MTM1, an enzyme whose loss of function leads to X-linked centronuclear myopathy (also called myotubular myopathy) in humans. Removal of endosomal PI(3)P by MTM1 is accompanied by phosphatidylinositol 4-kinase-2α (PI4K2α)-dependent generation of PI(4)P and recruitment of the exocyst tethering complex to enable membrane fusion. Our data establish a mechanism for phosphoinositide conversion from PI(3)P to PI(4)P at endosomes en route to the plasma membrane and suggest that defective phosphoinositide conversion at endosomes underlies X-linked centronuclear myopathy caused by mutation of MTM1 in humans." @default.
• W2259816268 created "2016-06-24" @default.
• W2259816268 creator A5007080521 @default.
• W2259816268 creator A5009134392 @default.
• W2259816268 creator A5010631390 @default.
• W2259816268 creator A5014760906 @default.
• W2259816268 creator A5020481419 @default.
• W2259816268 creator A5060477126 @default.
• W2259816268 creator A5069111179 @default.
• W2259816268 creator A5075639449 @default.
• W2259816268 creator A5081353001 @default.
• W2259816268 creator A5085289587 @default.
• W2259816268 date "2016-01-01" @default.
• W2259816268 modified "2023-09-30" @default.
• W2259816268 title "A phosphoinositide conversion mechanism for exit from endosomes" @default.
• W2259816268 cites W1966849450 @default.
• W2259816268 cites W1973230223 @default.
• W2259816268 cites W1978160140 @default.
• W2259816268 cites W1981015006 @default.
• W2259816268 cites W1983576132 @default.
• W2259816268 cites W2011520932 @default.
• W2259816268 cites W2020050184 @default.
• W2259816268 cites W2022421070 @default.
• W2259816268 cites W2028571598 @default.
• W2259816268 cites W2039987826 @default.
• W2259816268 cites W2050346490 @default.
• W2259816268 cites W2058706417 @default.
• W2259816268 cites W2065711215 @default.
• W2259816268 cites W2068752653 @default.
• W2259816268 cites W2082492086 @default.
• W2259816268 cites W2085035388 @default.
• W2259816268 cites W2091884933 @default.
• W2259816268 cites W2092215576 @default.
• W2259816268 cites W2093079184 @default.
• W2259816268 cites W2115990578 @default.
• W2259816268 cites W2135453787 @default.
• W2259816268 cites W2140522666 @default.
• W2259816268 cites W2140804868 @default.
• W2259816268 cites W2147711998 @default.
• W2259816268 cites W2162228329 @default.
• W2259816268 cites W2162889213 @default.
• W2259816268 cites W2165130769 @default.
• W2259816268 cites W2166019193 @default.
• W2259816268 cites W23176963 @default.
• W2259816268 cites W2319139363 @default.
• W2259816268 cites W2325065547 @default.
• W2259816268 cites W2326824347 @default.
• W2259816268 doi "https://doi.org/10.1038/nature16516" @default.
• W2259816268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26760201" @default.
• W2259816268 hasPublicationYear "2016" @default.
• W2259816268 type Work @default.
• W2259816268 sameAs 2259816268 @default.
• W2259816268 citedByCount "143" @default.
• W2259816268 countsByYear W22598162682016 @default.
• W2259816268 countsByYear W22598162682017 @default.
• W2259816268 countsByYear W22598162682018 @default.
• W2259816268 countsByYear W22598162682019 @default.
• W2259816268 countsByYear W22598162682020 @default.
• W2259816268 countsByYear W22598162682021 @default.
• W2259816268 countsByYear W22598162682022 @default.
• W2259816268 countsByYear W22598162682023 @default.
• W2259816268 crossrefType "journal-article" @default.
• W2259816268 hasAuthorship W2259816268A5007080521 @default.
• W2259816268 hasAuthorship W2259816268A5009134392 @default.
• W2259816268 hasAuthorship W2259816268A5010631390 @default.
• W2259816268 hasAuthorship W2259816268A5014760906 @default.
• W2259816268 hasAuthorship W2259816268A5020481419 @default.
• W2259816268 hasAuthorship W2259816268A5060477126 @default.
• W2259816268 hasAuthorship W2259816268A5069111179 @default.
• W2259816268 hasAuthorship W2259816268A5075639449 @default.
• W2259816268 hasAuthorship W2259816268A5081353001 @default.
• W2259816268 hasAuthorship W2259816268A5085289587 @default.
• W2259816268 hasBestOaLocation W22598162684 @default.
• W2259816268 hasConcept C102747710 @default.
• W2259816268 hasConcept C175969161 @default.
• W2259816268 hasConcept C184235292 @default.
• W2259816268 hasConcept C185592680 @default.
• W2259816268 hasConcept C2777853560 @default.
• W2259816268 hasConcept C2780610907 @default.
• W2259816268 hasConcept C41625074 @default.
• W2259816268 hasConcept C55493867 @default.
• W2259816268 hasConcept C79879829 @default.
• W2259816268 hasConcept C86803240 @default.
• W2259816268 hasConcept C95444343 @default.
• W2259816268 hasConceptScore W2259816268C102747710 @default.
• W2259816268 hasConceptScore W2259816268C175969161 @default.
• W2259816268 hasConceptScore W2259816268C184235292 @default.
• W2259816268 hasConceptScore W2259816268C185592680 @default.
• W2259816268 hasConceptScore W2259816268C2777853560 @default.
• W2259816268 hasConceptScore W2259816268C2780610907 @default.
• W2259816268 hasConceptScore W2259816268C41625074 @default.
• W2259816268 hasConceptScore W2259816268C55493867 @default.
• W2259816268 hasConceptScore W2259816268C79879829 @default.
• W2259816268 hasConceptScore W2259816268C86803240 @default.
• W2259816268 hasConceptScore W2259816268C95444343 @default.
• W2259816268 hasIssue "7586" @default.
• W2259816268 hasLocation W22598162681 @default.
• W2259816268 hasLocation W22598162682 @default.

• next