FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2259857027> ?p ?o ?g. }

• W2259857027 endingPage "2343" @default.
• W2259857027 startingPage "2341" @default.
• W2259857027 abstract "The global epidemic of obesity is constantly growing and represents an enormous challenge for health care systems worldwide. Obesity fuels the development of metabolic syndrome that includes components such as elevated glucose levels, insulin resistance, elevated blood pressure, and increased levels of triglycerides (1). Obesity and metabolic syndrome increase the risk of metabolic diseases, such as type 2 diabetes (T2D), cardiovascular disease, and atherosclerosis, and contribute to a reduction in life expectancy (2). In the U.S., the obesity rate in adults has reached 36% and obesity affects more than 1 billion people worldwide (3). Currently, 9.3% of the U.S. population has diabetes. In adults, T2D accounts for 90–95% of all diagnosed cases of diabetes, and the estimated total economic burden of diabetes in the U.S. is $245 billion (4). Thus, it is imperative that we increase our understanding of the mechanisms that lead to the development of obesity-induced insulin resistance and T2D, which will help identify therapeutic targets to reduce the impact of these syndromes on morbidity and mortality.The first piece of evidence that obesity, insulin resistance, and inflammation are interconnected was provided more than a century ago when Dr. R.T. Williamson (5) observed that the anti-inflammatory drug sodium salicylate improved glucose control in patients with diabetes. Almost 90 years later, Hotamisligil et al. (6) revisited this observation as they found that the neutralization of tumor necrosis factor (TNF)-α improved insulin resistance, and thus a link between inflammation and diet-induced insulin resistance was established. Subsequent studies elucidated that a complex immune cellular network regulates inflammation and insulin responsiveness in metabolic tissues. Recently, interleukin (IL)-1β antibodies in monotherapy or in …" @default.
• W2259857027 created "2016-06-24" @default.
• W2259857027 creator A5005635984 @default.
• W2259857027 creator A5048760718 @default.
• W2259857027 creator A5077174799 @default.
• W2259857027 creator A5084119264 @default.
• W2259857027 date "2015-06-17" @default.
• W2259857027 modified "2023-10-10" @default.
• W2259857027 title "New Piece in the Jigsaw Puzzle: Adipose Tissue–Derived Stem Cells From Obese Subjects Drive Th17 Polarization" @default.
• W2259857027 cites W1803405992 @default.
• W2259857027 cites W1960878940 @default.
• W2259857027 cites W1980619336 @default.
• W2259857027 cites W1982696151 @default.
• W2259857027 cites W1990967129 @default.
• W2259857027 cites W2000054651 @default.
• W2259857027 cites W2021240626 @default.
• W2259857027 cites W2024408216 @default.
• W2259857027 cites W2031549493 @default.
• W2259857027 cites W2054415546 @default.
• W2259857027 cites W2076205698 @default.
• W2259857027 cites W2107098508 @default.
• W2259857027 cites W2129316761 @default.
• W2259857027 cites W2145697808 @default.
• W2259857027 cites W2151172917 @default.
• W2259857027 cites W2166285548 @default.
• W2259857027 cites W2167823708 @default.
• W2259857027 cites W4313333839 @default.
• W2259857027 doi "https://doi.org/10.2337/db15-0437" @default.
• W2259857027 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4876753" @default.
• W2259857027 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26106197" @default.
• W2259857027 hasPublicationYear "2015" @default.
• W2259857027 type Work @default.
• W2259857027 sameAs 2259857027 @default.
• W2259857027 citedByCount "3" @default.
• W2259857027 countsByYear W22598570272018 @default.
• W2259857027 countsByYear W22598570272021 @default.
• W2259857027 countsByYear W22598570272023 @default.
• W2259857027 crossrefType "journal-article" @default.
• W2259857027 hasAuthorship W2259857027A5005635984 @default.
• W2259857027 hasAuthorship W2259857027A5048760718 @default.
• W2259857027 hasAuthorship W2259857027A5077174799 @default.
• W2259857027 hasAuthorship W2259857027A5084119264 @default.
• W2259857027 hasBestOaLocation W22598570272 @default.
• W2259857027 hasConcept C126322002 @default.
• W2259857027 hasConcept C134018914 @default.
• W2259857027 hasConcept C145420912 @default.
• W2259857027 hasConcept C15744967 @default.
• W2259857027 hasConcept C171089720 @default.
• W2259857027 hasConcept C2779405079 @default.
• W2259857027 hasConcept C71924100 @default.
• W2259857027 hasConceptScore W2259857027C126322002 @default.
• W2259857027 hasConceptScore W2259857027C134018914 @default.
• W2259857027 hasConceptScore W2259857027C145420912 @default.
• W2259857027 hasConceptScore W2259857027C15744967 @default.
• W2259857027 hasConceptScore W2259857027C171089720 @default.
• W2259857027 hasConceptScore W2259857027C2779405079 @default.
• W2259857027 hasConceptScore W2259857027C71924100 @default.
• W2259857027 hasIssue "7" @default.
• W2259857027 hasLocation W22598570271 @default.
• W2259857027 hasLocation W22598570272 @default.
• W2259857027 hasLocation W22598570273 @default.
• W2259857027 hasLocation W22598570274 @default.
• W2259857027 hasOpenAccess W2259857027 @default.
• W2259857027 hasPrimaryLocation W22598570271 @default.
• W2259857027 hasRelatedWork W1964688190 @default.
• W2259857027 hasRelatedWork W1976234278 @default.
• W2259857027 hasRelatedWork W1978718098 @default.
• W2259857027 hasRelatedWork W2017606817 @default.
• W2259857027 hasRelatedWork W2027098794 @default.
• W2259857027 hasRelatedWork W2049045125 @default.
• W2259857027 hasRelatedWork W2071032213 @default.
• W2259857027 hasRelatedWork W2081564223 @default.
• W2259857027 hasRelatedWork W2167541966 @default.
• W2259857027 hasRelatedWork W4253482381 @default.
• W2259857027 hasVolume "64" @default.
• W2259857027 isParatext "false" @default.
• W2259857027 isRetracted "false" @default.
• W2259857027 magId "2259857027" @default.
• W2259857027 workType "article" @default.