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• W2259948457 abstract "Arterial wall shear stress (WSS) parameters are widely used as prediction criteria for the initiation and development of atherosclerosis and arterial pathologies. However, clinical measurements of local WSS require complicated and expensive techniques and therefore traditional clinical evaluation of arterial condition relay mainly on flowrate and heart rate measurements. In this manuscript we show that heart rate and flowrate measurements are not sufficient for prediction of local WSS parameters and we suggest a third parameter based on the local pulsatility index (PI). The study includes experimental measurements of the flow profiles and WSS parameters of 16 different physiological flow waveforms in a straight arterial model. For each case, the phase-averaged velocity profiles were measured using digital particle image velocimetry techniques and were used to estimate WSS parameters utilizing the Womersley pulsating flow model. The results show that heart rate and flowrate parameters were not sufficient for prediction local WSS parameters for the 16 cases, while PI parameter exhibited well one-to-one correlation with WSS oscillatory index (OSI) and with the frequency of negative WSS occurrence (P[%]). In addition it provide a lowest limit for the peak-to-peak WSS ratios (min/max) for varying conditions. Therefore, PI was found to be an essential parameter for the complete description of the local WSS quantities for arterial flow." @default.
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• W2259948457 date "2013-03-15" @default.
• W2259948457 modified "2023-09-27" @default.
• W2259948457 title "Pulsatility index as a parameter for clinical diagnostics of vascular disease" @default.
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