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- W2259982045 abstract "Heart muscle contracts more vigorously when calcium levels are raised. A transient depletion of calcium from restricted extracellular spaces occurs with each contraction. We decided to maintain the concentration of this ion at a constant level by using an external calcium buffering system. It was found that buffering calcium at a millimolar level (using citrate as a buffer) caused a decrease, rather than an increase in the strength of contraction. The mean reduction in peak tension was by 27% in guinea pig and by 50.5% in frog atrium. This finding is analyzed; its most plausible explanation is the hypothesis that the buffer dissipates a calcium inhomogeneity, consisting of a higher calcium concentration adjacent to the membrane. Alternative interpretations such as intracellular acidosis, were tested experimentally and ruled out." @default.
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- W2259982045 date "1987-02-01" @default.
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- W2259982045 title "Negative inotropic effect of extracellular calcium buffering in cardiac muscle" @default.
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- W2259982045 doi "https://doi.org/10.1152/ajpcell.1987.252.2.c248" @default.
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