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- W2260135833 abstract "Angiogenesis is a central regulator for white (WAT) and brown (BAT) adipose tissue adaptation in the course of obesity. Here we show that deletion of hypoxia-inducible factor 2α (HIF2α) in adipocytes (by using Fabp4-Cre transgenic mice) but not in myeloid or endothelial cells negatively impacted WAT angiogenesis and promoted WAT inflammation, WAT dysfunction, hepatosteatosis, and systemic insulin resistance in obesity. Importantly, adipocyte HIF2α regulated vascular endothelial growth factor (VEGF) expression and angiogenesis of obese BAT as well as its thermogenic function. Consistently, obese adipocyte-specific HIF2α-deficient mice displayed BAT dysregulation, associated with reduced levels of uncoupling protein 1 (UCP1) and a dysfunctional thermogenic response to cold exposure. VEGF administration reversed WAT and BAT inflammation and BAT dysfunction in adipocyte HIF2α-deficient mice. Together, our findings show that adipocyte HIF2α is protective against maladaptation to obesity and metabolic dysregulation by promoting angiogenesis in both WAT and BAT and by counteracting obesity-mediated BAT dysfunction." @default.
- W2260135833 created "2016-06-24" @default.
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- W2260135833 date "2016-02-01" @default.
- W2260135833 modified "2023-10-18" @default.
- W2260135833 title "Adipocyte-Specific Hypoxia-Inducible Factor 2α Deficiency Exacerbates Obesity-Induced Brown Adipose Tissue Dysfunction and Metabolic Dysregulation" @default.
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- W2260135833 doi "https://doi.org/10.1128/mcb.00430-15" @default.
- W2260135833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4719429" @default.
- W2260135833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26572826" @default.
- W2260135833 hasPublicationYear "2016" @default.
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