Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260149075> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2260149075 abstract "Rheumatoid arthritis (RA) is a chronic autoimmune diseaseassociated with synovial inflammation, progressive cartilageand bone destruction. A hallmark of joint destruction in RA isdegradation of collagens, and other extracellular matrixcomponents. The group of matrix degrading enzymes matrixmetallo-proteinases (MMPs) and their tissue specific inhibitors(TIMPs) play crucial role in processes of tissue remodeling,join destruction and progression of RA. In a case-controlstudy, we explored relation between three polymorphisms innon-coding areas of TIMP1, TIMP2 and TIMP3 genes and rheumatoidarthritis, with respect to RA. A total of 94 patients withrheumatoid arthritis and 290 control subjects were genotypedfor G/C intron TIMP1polymorphism (rs5953060), A/G intron TIMP2polymorphism (rs8176329) and C/T 3UTR TIMP3 polymorphism(rs1065314). No significant differences in genotypedistribution and/or allele frequencies were observed whencomparing patients with rheumatoid arthritis and controls.Within the RA patient we have found significant associationbetween studied polymorphism in TIMP1 and levels of anti-CCP(p=0.047), rheumatoid factor (RF) (p=0.06), IL-15 (p=0.02) andIL-6 (p=0.06). Regarding the levels of pro-inflammatory IL-15and IL-6, the highest concentration was found in patientshomozygous for G allele. Furthermore, association of TIMP3polymorphism and distinct RF: RF IgM (p=0.08), RF IgA(p=0.04),RF IgG (p=0.01) and FW (p=0.06) have been observed. In case ofTIMP2 no association to factors of RA was found. In conclusion,the TIMP polymorphisms were not associated to RA, but TIMP-1and TIMP3 were related to pro-inflammatory cytokines levels incirculation and to RF and anti-CCP, respectively." @default.
- W2260149075 created "2016-06-24" @default.
- W2260149075 creator A5052187646 @default.
- W2260149075 creator A5070481254 @default.
- W2260149075 creator A5088183009 @default.
- W2260149075 date "2013-09-18" @default.
- W2260149075 modified "2023-10-04" @default.
- W2260149075 title "Polymorphisms in gene for TIMP1, TIMP2 and TIMP3 inrelationship to factors describing rheumatoid arthritis" @default.
- W2260149075 hasPublicationYear "2013" @default.
- W2260149075 type Work @default.
- W2260149075 sameAs 2260149075 @default.
- W2260149075 citedByCount "0" @default.
- W2260149075 crossrefType "journal-article" @default.
- W2260149075 hasAuthorship W2260149075A5052187646 @default.
- W2260149075 hasAuthorship W2260149075A5070481254 @default.
- W2260149075 hasAuthorship W2260149075A5088183009 @default.
- W2260149075 hasConcept C104317684 @default.
- W2260149075 hasConcept C126322002 @default.
- W2260149075 hasConcept C135763542 @default.
- W2260149075 hasConcept C150194340 @default.
- W2260149075 hasConcept C180754005 @default.
- W2260149075 hasConcept C203014093 @default.
- W2260149075 hasConcept C2776232647 @default.
- W2260149075 hasConcept C2777077863 @default.
- W2260149075 hasConcept C2777575956 @default.
- W2260149075 hasConcept C2780692422 @default.
- W2260149075 hasConcept C54355233 @default.
- W2260149075 hasConcept C71924100 @default.
- W2260149075 hasConcept C76252995 @default.
- W2260149075 hasConcept C86803240 @default.
- W2260149075 hasConceptScore W2260149075C104317684 @default.
- W2260149075 hasConceptScore W2260149075C126322002 @default.
- W2260149075 hasConceptScore W2260149075C135763542 @default.
- W2260149075 hasConceptScore W2260149075C150194340 @default.
- W2260149075 hasConceptScore W2260149075C180754005 @default.
- W2260149075 hasConceptScore W2260149075C203014093 @default.
- W2260149075 hasConceptScore W2260149075C2776232647 @default.
- W2260149075 hasConceptScore W2260149075C2777077863 @default.
- W2260149075 hasConceptScore W2260149075C2777575956 @default.
- W2260149075 hasConceptScore W2260149075C2780692422 @default.
- W2260149075 hasConceptScore W2260149075C54355233 @default.
- W2260149075 hasConceptScore W2260149075C71924100 @default.
- W2260149075 hasConceptScore W2260149075C76252995 @default.
- W2260149075 hasConceptScore W2260149075C86803240 @default.
- W2260149075 hasLocation W22601490751 @default.
- W2260149075 hasOpenAccess W2260149075 @default.
- W2260149075 hasPrimaryLocation W22601490751 @default.
- W2260149075 hasRelatedWork W2029323105 @default.
- W2260149075 hasRelatedWork W2092410077 @default.
- W2260149075 hasRelatedWork W2325350774 @default.
- W2260149075 hasRelatedWork W2350930824 @default.
- W2260149075 hasRelatedWork W2427370126 @default.
- W2260149075 hasRelatedWork W2428474659 @default.
- W2260149075 hasRelatedWork W2525825075 @default.
- W2260149075 hasRelatedWork W2563512063 @default.
- W2260149075 hasRelatedWork W2739707105 @default.
- W2260149075 hasRelatedWork W2896707886 @default.
- W2260149075 hasRelatedWork W2902342198 @default.
- W2260149075 hasRelatedWork W2908905579 @default.
- W2260149075 hasRelatedWork W2945752870 @default.
- W2260149075 hasRelatedWork W3022972584 @default.
- W2260149075 hasRelatedWork W3027847506 @default.
- W2260149075 hasRelatedWork W3081853140 @default.
- W2260149075 hasRelatedWork W3088429984 @default.
- W2260149075 hasRelatedWork W3093740571 @default.
- W2260149075 hasRelatedWork W3152721245 @default.
- W2260149075 hasRelatedWork W3145959424 @default.
- W2260149075 isParatext "false" @default.
- W2260149075 isRetracted "false" @default.
- W2260149075 magId "2260149075" @default.
- W2260149075 workType "article" @default.