Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260197997> ?p ?o ?g. }
- W2260197997 endingPage "21271" @default.
- W2260197997 startingPage "21259" @default.
- W2260197997 abstract "// Lorena Incorvaia 1,* , Giuseppe Bronte 1,* , Viviana Bazan 1,* , Giuseppe Badalamenti 1 , Sergio Rizzo 1 , Gianni Pantuso 2 , Clara Natoli 3 and Antonio Russo 1 1 Department of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, Palermo, Italy 2 Department of Surgical, Oncological and Oral Sciences, Section of Surgical Oncology, University of Palermo, Palermo, Italy 3 Department of Medical, Oral and Biotechnological Sciences, University “G. D’Annunzio”, Chieti, Italy * These authors have contributed equally to this work Correspondence to: Antonio Russo, email: // Keywords : renal cell cancer, tyrosine kinase inhibitor, mTOR, angiogenesis, VEGFr Received : November 09, 2015 Accepted : January 29, 2016 Published : February 08, 2016 Abstract The recent advances in identification of the molecular mechanisms related to tumorigenesis and angiogenesis, along with the understanding of molecular alterations involved in renal cell carcinoma (RCC) pathogenesis, has allowed the development of several new drugs which have revolutionized the treatment of metastatic renal cell carcinoma (mRCC). This process has resulted in clinically significant improvements in median overall survival and an increasing number of patients undergoes two or even three lines of therapy. Therefore, it is necessary a long-term perspective of the treatment: planning a sequential and personalized therapeutic strategy to improve clinical outcome, the potential to achieve long-term response, and to preserve quality of life (QOL), minimizing treatment-related toxicity and transforming mRCC into a chronically treatable condition. Because of the challenges still encountered to draw an optimal therapeutic sequence, the main focus of this article will be to propose the optimal sequencing of existing, approved, oral targeted agents for the treatment of mRCC using evidence-based data along with the knowledge available on the tumor behavior and mechanisms of resistance to anti-angiogenic treatment to provide complementary information and to help the clinicians to maximize the effectiveness of targeted agents in the treatment of mRCC." @default.
- W2260197997 created "2016-06-24" @default.
- W2260197997 creator A5004175335 @default.
- W2260197997 creator A5006712720 @default.
- W2260197997 creator A5017866134 @default.
- W2260197997 creator A5025654115 @default.
- W2260197997 creator A5027075905 @default.
- W2260197997 creator A5033609878 @default.
- W2260197997 creator A5056329331 @default.
- W2260197997 creator A5058543770 @default.
- W2260197997 date "2016-02-08" @default.
- W2260197997 modified "2023-09-24" @default.
- W2260197997 title "Beyond evidence-based data: scientific rationale and tumor behavior to drive sequential and personalized therapeutic strategies for the treatment of metastatic renal cell carcinoma" @default.
- W2260197997 cites W1536286673 @default.
- W2260197997 cites W1591039646 @default.
- W2260197997 cites W1663536395 @default.
- W2260197997 cites W1717153315 @default.
- W2260197997 cites W1867691097 @default.
- W2260197997 cites W1894437547 @default.
- W2260197997 cites W1910489037 @default.
- W2260197997 cites W1966280949 @default.
- W2260197997 cites W1967193000 @default.
- W2260197997 cites W1967287298 @default.
- W2260197997 cites W1971076526 @default.
- W2260197997 cites W1971705000 @default.
- W2260197997 cites W1973909484 @default.
- W2260197997 cites W1975864648 @default.
- W2260197997 cites W1977597655 @default.
- W2260197997 cites W1982861439 @default.
- W2260197997 cites W1990378122 @default.
- W2260197997 cites W1993205943 @default.
- W2260197997 cites W1994669778 @default.
- W2260197997 cites W1999966467 @default.
- W2260197997 cites W2007495351 @default.
- W2260197997 cites W2008701998 @default.
- W2260197997 cites W2017322644 @default.
- W2260197997 cites W2021888989 @default.
- W2260197997 cites W2023952988 @default.
- W2260197997 cites W2025196759 @default.
- W2260197997 cites W2027855911 @default.
- W2260197997 cites W2029229070 @default.
- W2260197997 cites W2036434473 @default.
- W2260197997 cites W2037716205 @default.
- W2260197997 cites W2038422485 @default.
- W2260197997 cites W2041899754 @default.
- W2260197997 cites W2045992174 @default.
- W2260197997 cites W2047871200 @default.
- W2260197997 cites W2053336880 @default.
- W2260197997 cites W2063526820 @default.
- W2260197997 cites W2067288907 @default.
- W2260197997 cites W2069417222 @default.
- W2260197997 cites W2069512383 @default.
- W2260197997 cites W2078020286 @default.
- W2260197997 cites W2088633031 @default.
- W2260197997 cites W2090693129 @default.
- W2260197997 cites W2092228974 @default.
- W2260197997 cites W2094935740 @default.
- W2260197997 cites W2095867755 @default.
- W2260197997 cites W2096514839 @default.
- W2260197997 cites W2099088585 @default.
- W2260197997 cites W2100669312 @default.
- W2260197997 cites W2101670384 @default.
- W2260197997 cites W2102478789 @default.
- W2260197997 cites W2102575291 @default.
- W2260197997 cites W2102712762 @default.
- W2260197997 cites W2102900043 @default.
- W2260197997 cites W2105569425 @default.
- W2260197997 cites W2106932520 @default.
- W2260197997 cites W2112003796 @default.
- W2260197997 cites W2114991862 @default.
- W2260197997 cites W2115005218 @default.
- W2260197997 cites W2115155004 @default.
- W2260197997 cites W2115966993 @default.
- W2260197997 cites W2116949558 @default.
- W2260197997 cites W2117547860 @default.
- W2260197997 cites W2117924296 @default.
- W2260197997 cites W2118677643 @default.
- W2260197997 cites W2122891049 @default.
- W2260197997 cites W2127385754 @default.
- W2260197997 cites W2130828569 @default.
- W2260197997 cites W2134131507 @default.
- W2260197997 cites W2134793155 @default.
- W2260197997 cites W2136110110 @default.
- W2260197997 cites W2138129102 @default.
- W2260197997 cites W2139877124 @default.
- W2260197997 cites W2141444851 @default.
- W2260197997 cites W2143782771 @default.
- W2260197997 cites W2148706732 @default.
- W2260197997 cites W2149456801 @default.
- W2260197997 cites W2152694160 @default.
- W2260197997 cites W2153867442 @default.
- W2260197997 cites W2155012968 @default.
- W2260197997 cites W2159183653 @default.
- W2260197997 cites W2160476851 @default.
- W2260197997 cites W2160724351 @default.
- W2260197997 cites W2162424705 @default.
- W2260197997 cites W2164638888 @default.
- W2260197997 cites W2166010840 @default.