Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260312731> ?p ?o ?g. }
- W2260312731 endingPage "6665" @default.
- W2260312731 startingPage "6607" @default.
- W2260312731 abstract "Ras proteins are classical members of small GTPases that function as molecular switches by alternating between inactive GDP-bound and active GTP-bound states. Ras activation is regulated by guanine nucleotide exchange factors that catalyze the exchange of GDP by GTP, and inactivation is terminated by GTPase-activating proteins that accelerate the intrinsic GTP hydrolysis rate by orders of magnitude. In this review, we focus on data that have accumulated over the past few years pertaining to the conformational ensembles and the allosteric regulation of Ras proteins and their interpretation from our conformational landscape standpoint. The Ras ensemble embodies all states, including the ligand-bound conformations, the activated (or inactivated) allosteric modulated states, post-translationally modified states, mutational states, transition states, and nonfunctional states serving as a reservoir for emerging functions. The ensemble is shifted by distinct mutational events, cofactors, post-translational modifications, and different membrane compositions. A better understanding of Ras biology can contribute to therapeutic strategies." @default.
- W2260312731 created "2016-06-24" @default.
- W2260312731 creator A5025357844 @default.
- W2260312731 creator A5036278069 @default.
- W2260312731 creator A5049338114 @default.
- W2260312731 creator A5057115991 @default.
- W2260312731 creator A5071084031 @default.
- W2260312731 creator A5073875725 @default.
- W2260312731 creator A5085916857 @default.
- W2260312731 date "2016-01-27" @default.
- W2260312731 modified "2023-10-13" @default.
- W2260312731 title "Ras Conformational Ensembles, Allostery, and Signaling" @default.
- W2260312731 cites W131401516 @default.
- W2260312731 cites W1486102976 @default.
- W2260312731 cites W1492513673 @default.
- W2260312731 cites W1498171831 @default.
- W2260312731 cites W1500297039 @default.
- W2260312731 cites W1529338850 @default.
- W2260312731 cites W1533028780 @default.
- W2260312731 cites W1535997186 @default.
- W2260312731 cites W1545231234 @default.
- W2260312731 cites W1549268831 @default.
- W2260312731 cites W1581417572 @default.
- W2260312731 cites W1587767001 @default.
- W2260312731 cites W1608936317 @default.
- W2260312731 cites W1622452078 @default.
- W2260312731 cites W1672842817 @default.
- W2260312731 cites W1750186366 @default.
- W2260312731 cites W1774371590 @default.
- W2260312731 cites W1824220821 @default.
- W2260312731 cites W1833275968 @default.
- W2260312731 cites W1833693759 @default.
- W2260312731 cites W1839280013 @default.
- W2260312731 cites W1852817901 @default.
- W2260312731 cites W1857112241 @default.
- W2260312731 cites W1866462462 @default.
- W2260312731 cites W1869861415 @default.
- W2260312731 cites W1873642659 @default.
- W2260312731 cites W1884928912 @default.
- W2260312731 cites W1897773958 @default.
- W2260312731 cites W1908759766 @default.
- W2260312731 cites W1916470139 @default.
- W2260312731 cites W1946879166 @default.
- W2260312731 cites W1953264505 @default.
- W2260312731 cites W1957889134 @default.
- W2260312731 cites W1958742527 @default.
- W2260312731 cites W1960357661 @default.
- W2260312731 cites W1961936302 @default.
- W2260312731 cites W1963547997 @default.
- W2260312731 cites W1964439982 @default.
- W2260312731 cites W1964930474 @default.
- W2260312731 cites W1966104308 @default.
- W2260312731 cites W1967767166 @default.
- W2260312731 cites W1968075591 @default.
- W2260312731 cites W1968910405 @default.
- W2260312731 cites W1969292035 @default.
- W2260312731 cites W1970161309 @default.
- W2260312731 cites W1970527559 @default.
- W2260312731 cites W1970694857 @default.
- W2260312731 cites W1970730325 @default.
- W2260312731 cites W1970856032 @default.
- W2260312731 cites W1970958467 @default.
- W2260312731 cites W1971102429 @default.
- W2260312731 cites W1971103887 @default.
- W2260312731 cites W1971187774 @default.
- W2260312731 cites W1971430873 @default.
- W2260312731 cites W1971791161 @default.
- W2260312731 cites W1971891434 @default.
- W2260312731 cites W1971917925 @default.
- W2260312731 cites W1972233461 @default.
- W2260312731 cites W1973006797 @default.
- W2260312731 cites W1973075342 @default.
- W2260312731 cites W1973728462 @default.
- W2260312731 cites W1974140340 @default.
- W2260312731 cites W1974289014 @default.
- W2260312731 cites W1974393170 @default.
- W2260312731 cites W1974447388 @default.
- W2260312731 cites W1974956364 @default.
- W2260312731 cites W1975757940 @default.
- W2260312731 cites W1976051941 @default.
- W2260312731 cites W1976170436 @default.
- W2260312731 cites W1976360756 @default.
- W2260312731 cites W1976702450 @default.
- W2260312731 cites W1976973627 @default.
- W2260312731 cites W1977375333 @default.
- W2260312731 cites W1977598234 @default.
- W2260312731 cites W1977604387 @default.
- W2260312731 cites W1978609220 @default.
- W2260312731 cites W1978998033 @default.
- W2260312731 cites W1979116048 @default.
- W2260312731 cites W1980323101 @default.
- W2260312731 cites W1981711832 @default.
- W2260312731 cites W1982433403 @default.
- W2260312731 cites W1982586481 @default.
- W2260312731 cites W1982929992 @default.
- W2260312731 cites W1984002284 @default.
- W2260312731 cites W1984521949 @default.
- W2260312731 cites W1984533380 @default.