Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260409648> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2260409648 endingPage "737" @default.
- W2260409648 startingPage "730" @default.
- W2260409648 abstract "Robustness, the ability of biological networks to uphold their functionality in spite of perturbations, is a key characteristic of all living systems. Although several theoretical approaches have been developed to formalize robustness, it still eludes an exact quantification. Here, we present a rigorous and quantitative approach for the structural robustness of metabolic networks by measuring their ability to tolerate random reaction (or gene) knockouts.In analogy to reliability theory, based on an explicit consideration of all possible knockout sets, we exactly quantify the probability of failure for a given network function (e.g. growth). This measure can be computed if the network's minimal cut sets (MSCs) are known. We show that even in genome-scale metabolic networks the probability of (network) failure can be reliably estimated from MSCs with lowest cardinalities. We demonstrate the applicability of our theory by analyzing the structural robustness of multiple Enterobacteriaceae and Blattibacteriaceae and show a dramatically low structural robustness for the latter. We find that structural robustness develops from the ability to proliferate in multiple growth environments consistent with experimentally found knowledge.The probability of (network) failure provides thus a reliable and easily computable measure of structural robustness and redundancy in (genome-scale) metabolic networks.Source code is available under the GNU General Public License at https://github.com/mpgerstl/networkRobustnessToolboxjuergen.zanghellini@boku.ac.atSupplementary data are available at Bioinformatics online." @default.
- W2260409648 created "2016-06-24" @default.
- W2260409648 creator A5015293905 @default.
- W2260409648 creator A5035360801 @default.
- W2260409648 creator A5053663717 @default.
- W2260409648 creator A5080707502 @default.
- W2260409648 date "2015-11-04" @default.
- W2260409648 modified "2023-10-16" @default.
- W2260409648 title "Exact quantification of cellular robustness in genome-scale metabolic networks" @default.
- W2260409648 cites W141572739 @default.
- W2260409648 cites W1758395617 @default.
- W2260409648 cites W1977199071 @default.
- W2260409648 cites W1978486653 @default.
- W2260409648 cites W1979833590 @default.
- W2260409648 cites W1996893186 @default.
- W2260409648 cites W2009282793 @default.
- W2260409648 cites W2011880165 @default.
- W2260409648 cites W2017855215 @default.
- W2260409648 cites W2019385975 @default.
- W2260409648 cites W2039119507 @default.
- W2260409648 cites W2043440339 @default.
- W2260409648 cites W2055166749 @default.
- W2260409648 cites W2055611983 @default.
- W2260409648 cites W2082271814 @default.
- W2260409648 cites W2083693802 @default.
- W2260409648 cites W2085529772 @default.
- W2260409648 cites W2085993965 @default.
- W2260409648 cites W2094097101 @default.
- W2260409648 cites W2094399313 @default.
- W2260409648 cites W2094525983 @default.
- W2260409648 cites W2117842011 @default.
- W2260409648 cites W2127844534 @default.
- W2260409648 cites W2142072523 @default.
- W2260409648 cites W2144372567 @default.
- W2260409648 cites W2148904859 @default.
- W2260409648 cites W2161827792 @default.
- W2260409648 cites W2164904029 @default.
- W2260409648 cites W2172275102 @default.
- W2260409648 cites W4243285511 @default.
- W2260409648 doi "https://doi.org/10.1093/bioinformatics/btv649" @default.
- W2260409648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4795620" @default.
- W2260409648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26543173" @default.
- W2260409648 hasPublicationYear "2015" @default.
- W2260409648 type Work @default.
- W2260409648 sameAs 2260409648 @default.
- W2260409648 citedByCount "13" @default.
- W2260409648 countsByYear W22604096482016 @default.
- W2260409648 countsByYear W22604096482017 @default.
- W2260409648 countsByYear W22604096482018 @default.
- W2260409648 countsByYear W22604096482020 @default.
- W2260409648 crossrefType "journal-article" @default.
- W2260409648 hasAuthorship W2260409648A5015293905 @default.
- W2260409648 hasAuthorship W2260409648A5035360801 @default.
- W2260409648 hasAuthorship W2260409648A5053663717 @default.
- W2260409648 hasAuthorship W2260409648A5080707502 @default.
- W2260409648 hasBestOaLocation W22604096481 @default.
- W2260409648 hasConcept C104317684 @default.
- W2260409648 hasConcept C124101348 @default.
- W2260409648 hasConcept C150194340 @default.
- W2260409648 hasConcept C41008148 @default.
- W2260409648 hasConcept C54355233 @default.
- W2260409648 hasConcept C63479239 @default.
- W2260409648 hasConcept C67339327 @default.
- W2260409648 hasConcept C80444323 @default.
- W2260409648 hasConcept C86803240 @default.
- W2260409648 hasConceptScore W2260409648C104317684 @default.
- W2260409648 hasConceptScore W2260409648C124101348 @default.
- W2260409648 hasConceptScore W2260409648C150194340 @default.
- W2260409648 hasConceptScore W2260409648C41008148 @default.
- W2260409648 hasConceptScore W2260409648C54355233 @default.
- W2260409648 hasConceptScore W2260409648C63479239 @default.
- W2260409648 hasConceptScore W2260409648C67339327 @default.
- W2260409648 hasConceptScore W2260409648C80444323 @default.
- W2260409648 hasConceptScore W2260409648C86803240 @default.
- W2260409648 hasIssue "5" @default.
- W2260409648 hasLocation W22604096481 @default.
- W2260409648 hasLocation W22604096482 @default.
- W2260409648 hasLocation W22604096483 @default.
- W2260409648 hasLocation W22604096484 @default.
- W2260409648 hasLocation W22604096485 @default.
- W2260409648 hasOpenAccess W2260409648 @default.
- W2260409648 hasPrimaryLocation W22604096481 @default.
- W2260409648 hasRelatedWork W1980122825 @default.
- W2260409648 hasRelatedWork W2041409583 @default.
- W2260409648 hasRelatedWork W2130291733 @default.
- W2260409648 hasRelatedWork W2147898386 @default.
- W2260409648 hasRelatedWork W2347219288 @default.
- W2260409648 hasRelatedWork W2366221835 @default.
- W2260409648 hasRelatedWork W2547726073 @default.
- W2260409648 hasRelatedWork W2747163143 @default.
- W2260409648 hasRelatedWork W2982120224 @default.
- W2260409648 hasRelatedWork W4384398219 @default.
- W2260409648 hasVolume "32" @default.
- W2260409648 isParatext "false" @default.
- W2260409648 isRetracted "false" @default.
- W2260409648 magId "2260409648" @default.
- W2260409648 workType "article" @default.