Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260421148> ?p ?o ?g. }
- W2260421148 endingPage "79" @default.
- W2260421148 startingPage "69" @default.
- W2260421148 abstract "Radial glial cells (RGCs) in teleost brain are progenitor cells that express aromatase B and produce estrogens. Controversial data suggest that estrogens are critical for brain repair and neurogenesis in teleosts. Using a goldfish model for neurotoxin-induced Parkinson-like syndrome, we investigated the possible roles of RGCs, especially estrogen synthetic function, in the processes underlying dopamine neuron regeneration. The data indicate that dopamine neuron degeneration and aromatase activity inhibition could be respectively achieved in vivo with treatments with the neurotoxin 1-methyl-1,2,3,6-tetrahydropyridine (MPTP) and fadrozole in female goldfish. The expression of genes in the telencephalon and hypothalamus related to RGC functions including gfap, gdnf and bdnf as well as genes related to mature dopamine neuron functions including th, slc6a3 and pitx3 are under modulation of estrogens. Together these results revealed that the activation of radial glial cells and dopamine neuron recovery after MPTP insult is aromatase-dependent. Findings in this study provide support for the hypothesis that endogenous estrogens are neuroprotective in goldfish. Future studies focus on the molecular pathways for enhancing protective functions of estrogens and understanding global effects of estrogens in the central nervous system." @default.
- W2260421148 created "2016-06-24" @default.
- W2260421148 creator A5004819710 @default.
- W2260421148 creator A5005967185 @default.
- W2260421148 creator A5011853405 @default.
- W2260421148 date "2017-01-01" @default.
- W2260421148 modified "2023-10-01" @default.
- W2260421148 title "Role of aromatase and radial glial cells in neurotoxin-induced dopamine neuron degeneration and regeneration" @default.
- W2260421148 cites W1606562123 @default.
- W2260421148 cites W1622476634 @default.
- W2260421148 cites W1771495220 @default.
- W2260421148 cites W1963951882 @default.
- W2260421148 cites W1964898022 @default.
- W2260421148 cites W1966624755 @default.
- W2260421148 cites W1969128883 @default.
- W2260421148 cites W1969311370 @default.
- W2260421148 cites W1973762720 @default.
- W2260421148 cites W1974725025 @default.
- W2260421148 cites W1977710838 @default.
- W2260421148 cites W1983450321 @default.
- W2260421148 cites W1983871586 @default.
- W2260421148 cites W1991966343 @default.
- W2260421148 cites W1992325863 @default.
- W2260421148 cites W1999495459 @default.
- W2260421148 cites W2002506451 @default.
- W2260421148 cites W2019146253 @default.
- W2260421148 cites W2023211111 @default.
- W2260421148 cites W2024089136 @default.
- W2260421148 cites W2026674733 @default.
- W2260421148 cites W2036928362 @default.
- W2260421148 cites W2041683554 @default.
- W2260421148 cites W2050865611 @default.
- W2260421148 cites W2054810445 @default.
- W2260421148 cites W2055671159 @default.
- W2260421148 cites W2056053755 @default.
- W2260421148 cites W2056287103 @default.
- W2260421148 cites W2056413071 @default.
- W2260421148 cites W2058075792 @default.
- W2260421148 cites W2060731374 @default.
- W2260421148 cites W2069823146 @default.
- W2260421148 cites W2069971359 @default.
- W2260421148 cites W2077613782 @default.
- W2260421148 cites W2078826387 @default.
- W2260421148 cites W2081794891 @default.
- W2260421148 cites W2083569948 @default.
- W2260421148 cites W2085921200 @default.
- W2260421148 cites W2086061893 @default.
- W2260421148 cites W2092357505 @default.
- W2260421148 cites W2092394440 @default.
- W2260421148 cites W2094706086 @default.
- W2260421148 cites W2108204976 @default.
- W2260421148 cites W2108336333 @default.
- W2260421148 cites W2110347660 @default.
- W2260421148 cites W2113701896 @default.
- W2260421148 cites W2118096701 @default.
- W2260421148 cites W2118441542 @default.
- W2260421148 cites W2119791710 @default.
- W2260421148 cites W2120275228 @default.
- W2260421148 cites W2123460738 @default.
- W2260421148 cites W2123515360 @default.
- W2260421148 cites W2126967674 @default.
- W2260421148 cites W2127673211 @default.
- W2260421148 cites W2139350439 @default.
- W2260421148 cites W2140360329 @default.
- W2260421148 cites W2140850665 @default.
- W2260421148 cites W2142022230 @default.
- W2260421148 cites W2145362441 @default.
- W2260421148 cites W2149623529 @default.
- W2260421148 cites W2154273881 @default.
- W2260421148 cites W2157704923 @default.
- W2260421148 cites W2164975725 @default.
- W2260421148 cites W2167183795 @default.
- W2260421148 cites W2169174542 @default.
- W2260421148 cites W2169622817 @default.
- W2260421148 cites W220741418 @default.
- W2260421148 cites W2273336351 @default.
- W2260421148 cites W2742934657 @default.
- W2260421148 cites W1971182106 @default.
- W2260421148 doi "https://doi.org/10.1016/j.ygcen.2016.02.011" @default.
- W2260421148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26873632" @default.
- W2260421148 hasPublicationYear "2017" @default.
- W2260421148 type Work @default.
- W2260421148 sameAs 2260421148 @default.
- W2260421148 citedByCount "9" @default.
- W2260421148 countsByYear W22604211482017 @default.
- W2260421148 countsByYear W22604211482018 @default.
- W2260421148 countsByYear W22604211482020 @default.
- W2260421148 countsByYear W22604211482021 @default.
- W2260421148 countsByYear W22604211482022 @default.
- W2260421148 countsByYear W22604211482023 @default.
- W2260421148 crossrefType "journal-article" @default.
- W2260421148 hasAuthorship W2260421148A5004819710 @default.
- W2260421148 hasAuthorship W2260421148A5005967185 @default.
- W2260421148 hasAuthorship W2260421148A5011853405 @default.
- W2260421148 hasConcept C121608353 @default.
- W2260421148 hasConcept C126322002 @default.
- W2260421148 hasConcept C134018914 @default.
- W2260421148 hasConcept C137183658 @default.