Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260532911> ?p ?o ?g. }
- W2260532911 endingPage "34" @default.
- W2260532911 startingPage "729" @default.
- W2260532911 abstract "Unfractionated heparin (UFH) and enoxaparin (low molecular weight heparin) constitute fundamental therapies in the treatment of patients with acute coronary syndrome (ACS). Since enoxaparin appears to offer clinical advantages over UFH in managing ACS, markers of thrombin generation, endothelial function and acute phase response could manifest different responses to UFH or enoxaparin. The purpose of the present study was to investigate the effect that treatment with either UFH or enoxaparin has on plasma hemostatic markers in 24 patients with ACS.The patients were randomized to receive 5,000 IU intravenous bolus and continuous infusion of 18 IU/Kg/h UFH (n=11) or 1 mg/kg/12h subcutaneous enoxaparin (n=13). The plasma levels of fibrinogen (Fg), prothrombin fragment 1+2 (F1+2), thrombin antithrombin complex (TAT), von Willebrand factor (vWF), tissue factor (TF) and tissue factor pathway inhibitor (TFPI) were assayed at admission and 6, 12, 24 and 48 hours after heparin treatment.Upon admission, UFH and enoxaparin patients showed a significant increase in all the hemostatic parameters measured with respect to the levels in the control subjects. In comparison with the baseline levels of the UFH- and enoxaparin-treated patients, Fg showed a significant increase at 48 h and TFPI at 6, 12 and 24 hours. However, at 48 hours TFPI levels were not significantly higher than the basal values. There were no significant changes in F1+2, TAT, vWF or TF.Markers of thrombin generation, endothelial function and acute-phase reactants manifest a similar response to UFH and enoxaparin. An increase in thrombin generation may be a result of persistently activated inflammatory and endothelial processes, despite UFH and enoxaparin treatment." @default.
- W2260532911 created "2016-06-24" @default.
- W2260532911 creator A5004466207 @default.
- W2260532911 creator A5029943902 @default.
- W2260532911 creator A5043490633 @default.
- W2260532911 creator A5049551537 @default.
- W2260532911 creator A5075161508 @default.
- W2260532911 creator A5078446903 @default.
- W2260532911 creator A5085981215 @default.
- W2260532911 date "2001-07-01" @default.
- W2260532911 modified "2023-10-17" @default.
- W2260532911 title "Effects of unfractionated and low molecular weight heparins on plasma levels of hemostatic factors in patients with acute coronary syndromes." @default.
- W2260532911 cites W113985811 @default.
- W2260532911 cites W1549602366 @default.
- W2260532911 cites W1651383390 @default.
- W2260532911 cites W1808267078 @default.
- W2260532911 cites W183837767 @default.
- W2260532911 cites W1975161958 @default.
- W2260532911 cites W1995973788 @default.
- W2260532911 cites W1996102904 @default.
- W2260532911 cites W2008589296 @default.
- W2260532911 cites W2012328700 @default.
- W2260532911 cites W2020237087 @default.
- W2260532911 cites W2026740600 @default.
- W2260532911 cites W2032105970 @default.
- W2260532911 cites W2040014365 @default.
- W2260532911 cites W2047172923 @default.
- W2260532911 cites W2048587766 @default.
- W2260532911 cites W2062893657 @default.
- W2260532911 cites W2064020544 @default.
- W2260532911 cites W2081356898 @default.
- W2260532911 cites W2088634712 @default.
- W2260532911 cites W2102786031 @default.
- W2260532911 cites W2114055583 @default.
- W2260532911 cites W2149599987 @default.
- W2260532911 cites W2180149684 @default.
- W2260532911 cites W2186548824 @default.
- W2260532911 cites W2217969591 @default.
- W2260532911 cites W2226476147 @default.
- W2260532911 cites W2316460201 @default.
- W2260532911 cites W2325460018 @default.
- W2260532911 cites W2412835183 @default.
- W2260532911 cites W2414976150 @default.
- W2260532911 cites W2415752756 @default.
- W2260532911 cites W2474172275 @default.
- W2260532911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11454528" @default.
- W2260532911 hasPublicationYear "2001" @default.
- W2260532911 type Work @default.
- W2260532911 sameAs 2260532911 @default.
- W2260532911 citedByCount "6" @default.
- W2260532911 countsByYear W22605329112018 @default.
- W2260532911 crossrefType "journal-article" @default.
- W2260532911 hasAuthorship W2260532911A5004466207 @default.
- W2260532911 hasAuthorship W2260532911A5029943902 @default.
- W2260532911 hasAuthorship W2260532911A5043490633 @default.
- W2260532911 hasAuthorship W2260532911A5049551537 @default.
- W2260532911 hasAuthorship W2260532911A5075161508 @default.
- W2260532911 hasAuthorship W2260532911A5078446903 @default.
- W2260532911 hasAuthorship W2260532911A5085981215 @default.
- W2260532911 hasConcept C126322002 @default.
- W2260532911 hasConcept C186738567 @default.
- W2260532911 hasConcept C2776884760 @default.
- W2260532911 hasConcept C2777151630 @default.
- W2260532911 hasConcept C2777292125 @default.
- W2260532911 hasConcept C2777557582 @default.
- W2260532911 hasConcept C2777698277 @default.
- W2260532911 hasConcept C2778382381 @default.
- W2260532911 hasConcept C2778589496 @default.
- W2260532911 hasConcept C2778825682 @default.
- W2260532911 hasConcept C2779026020 @default.
- W2260532911 hasConcept C2779036427 @default.
- W2260532911 hasConcept C2779394231 @default.
- W2260532911 hasConcept C43376680 @default.
- W2260532911 hasConcept C500558357 @default.
- W2260532911 hasConcept C71924100 @default.
- W2260532911 hasConcept C89560881 @default.
- W2260532911 hasConcept C90924648 @default.
- W2260532911 hasConceptScore W2260532911C126322002 @default.
- W2260532911 hasConceptScore W2260532911C186738567 @default.
- W2260532911 hasConceptScore W2260532911C2776884760 @default.
- W2260532911 hasConceptScore W2260532911C2777151630 @default.
- W2260532911 hasConceptScore W2260532911C2777292125 @default.
- W2260532911 hasConceptScore W2260532911C2777557582 @default.
- W2260532911 hasConceptScore W2260532911C2777698277 @default.
- W2260532911 hasConceptScore W2260532911C2778382381 @default.
- W2260532911 hasConceptScore W2260532911C2778589496 @default.
- W2260532911 hasConceptScore W2260532911C2778825682 @default.
- W2260532911 hasConceptScore W2260532911C2779026020 @default.
- W2260532911 hasConceptScore W2260532911C2779036427 @default.
- W2260532911 hasConceptScore W2260532911C2779394231 @default.
- W2260532911 hasConceptScore W2260532911C43376680 @default.
- W2260532911 hasConceptScore W2260532911C500558357 @default.
- W2260532911 hasConceptScore W2260532911C71924100 @default.
- W2260532911 hasConceptScore W2260532911C89560881 @default.
- W2260532911 hasConceptScore W2260532911C90924648 @default.
- W2260532911 hasIssue "7" @default.
- W2260532911 hasLocation W22605329111 @default.
- W2260532911 hasOpenAccess W2260532911 @default.