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- W2260556585 abstract "PurposeTo investigate impact of transplanted peripheral glia on neurites outgrowth and synaptogenesis in adult rat retina associated with ongoing optic neuropathy.MethodsIn this study we used two models of retinal neurodegeneration – degeneration of denervation represented by retinal explants culture and glaucomatous degeneration represented by rat model of ocular hypertension. Retinal explants were cultured in standard supplemented Neurobasal A medium (n = 48). Ocular hypertension has been induced using beads occlusive model (n = 10). In both ex vivo and in vivo approaches we applied transplantation of peripheral glia, prepared as previously described (Marcol et al. 2015), of density 104/5 µl for ex vivo and 106/5 µl for in vivo. PBS treatment was used as a control. After proper follow-up time (10 days for retinal explants and 6 weeks for glaucoma model), tissue was fixed and processed for immunostaining (GAP43, synaptophysin, mGlu2/3R) and stereological analyses.ResultsThere were visible differences in GAP43, synaptophysin and mGlu2/3R staining between experimental groups. Treatment with peripheral glia increased expression of above proteins both ex vivo and in vivo. Synaptic proteins expression was increased in glial cells treated glaucomatous retinas with mostly within inner plexiform layer, however punctate staining appeared also in ganglion cells layer and retinal nerve fiber layer that might be associated with synaptic plasticity induced by our treatment. Retinal explants analyzed in stereology revealed significant differences expressed in parameters of neurites outgrowth (U-Mann Whitney test, p < 0.05).ConclusionsTransplantation of in vivo modified peripheral glia support regeneration and might have impact on synaptogenesis and synaptic plasticity within inner rat retina." @default.
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- W2260556585 date "2015-09-23" @default.
- W2260556585 modified "2023-10-18" @default.
- W2260556585 title "In vivo modified peripheral glia enhance regenerative capacity in a rat retina" @default.
- W2260556585 doi "https://doi.org/10.1111/j.1755-3768.2015.0502" @default.
- W2260556585 hasPublicationYear "2015" @default.
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