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- W2260654513 abstract "Cocrystallization of pyridoxine (vitamin B6) with several biologically important molecules was undertaken with the intent of successfully designing various hydrogen bonded adducts such as salts, cocrystals, and eutectics. Pyridoxine formed eutectics with isoniazid (an antitubercular drug) and nicotinic acid (vitamin B3) and molecular salts with para-aminobenzoic acid (a bioactive) and saccharin (an artificial sweetener), respectively, in accordance to our design strategy. A salt cocrystal, a precisely conjugate acid–base cocrystal, was obtained for the pyridoxine–para-nitrobenzoic acid combination. The role of supramolecular affinity of hydrogen bonding functional groups and ΔpKa differences’ leading to the formation of above diverse adducts was discussed. This study underpins the need for full-fledged supramolecular compatibility studies of multivitamin/drug combinations toward the development of optimal and/or synergistic combination formulations." @default.
- W2260654513 created "2016-06-24" @default.
- W2260654513 creator A5013879487 @default.
- W2260654513 creator A5040638988 @default.
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- W2260654513 date "2015-06-17" @default.
- W2260654513 modified "2023-09-24" @default.
- W2260654513 title "Multicomponent Adducts of Pyridoxine: An Evaluation of the Formation of Eutectics and Molecular Salts" @default.
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- W2260654513 doi "https://doi.org/10.1021/acs.cgd.5b00546" @default.
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