FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260696588> ?p ?o ?g. }

• W2260696588 endingPage "20576" @default.
• W2260696588 startingPage "20576" @default.
• W2260696588 abstract "20576 Background: Treating the octogenarian and nonagenarianAML pts with intensive chemotherapy is controversial. Several models to predict outcome have been proposed including the use of a comorbidity index. However, it is unclear whether the Charlson Comorbidity Index (CCI) or the Hematopoietic Cell Transplant Comorbidity Index (HCTCI) is more sensitive. Methods: We analyzed our experience with 92 AML pts ≥80 years old evaluated at Roswell Park Cancer Institute between the years 1991 and 2007. We recorded pts’ age, gender, performance status, albumin, lactic dehydrogenase, hemoglobin, white blood cell and platelet counts, peripheral blood blast percentage, CD34 and CD56 positivity of the leukemic blasts, karyotype, de novo vs. secondary AML, CCI and HCTCI, and treatment outcome. Results: All pts were offered intensive treatment (IT); 59 (64%) pts were treated intensively with a variety of regimens while 33 (36%) pts elected to receive supportive care (SC). CCI and HCTCI had similar predictive ability for outcome in both groups. The 2 groups had similar pretreatment characteristics except that there were more pts with unfavorable karyotype in the IT group (P=0.0376). There was no significant difference between IT and SC pts in regards to overall survival (OS) though among the IT pts, those who achieved complete remission had a significantly longer OS (median 39.5 weeks) than those who did not (median 9 weeks; P=0.0024). A favorable group within the IT cohort with albumin ≥3.4g/L (51% of the treated pts) had a 1-year survival rate >33%; there was significant difference between the 2 albumin groups for OS in the IT cohort (P=0.0012). Similarly, a favorable group within the SC cohort with peripheral blood blasts <46% (50% of the pts) had a 1-year survival rate >20%; there was significant difference between the 2 peripheral blood blast percentage groups for OS in the SC cohort (P=0.0053). Conclusions: This retrospective analysis revealed no difference in outcome prediction between CCI and HCTCI for AML pts ≥80 years old. This analysis suggested an association between favorable outcome and near normal albumin level in IT elderly AML pts and low peripheral blood blast percentage in AML pts treated with SC. These findings require further validation in a prospective study. No significant financial relationships to disclose." @default.
• W2260696588 created "2016-06-24" @default.
• W2260696588 creator A5008341315 @default.
• W2260696588 creator A5010060503 @default.
• W2260696588 creator A5016601438 @default.
• W2260696588 creator A5025455280 @default.
• W2260696588 creator A5033926779 @default.
• W2260696588 creator A5039028985 @default.
• W2260696588 creator A5065404552 @default.
• W2260696588 creator A5066931842 @default.
• W2260696588 creator A5077133890 @default.
• W2260696588 creator A5080701625 @default.
• W2260696588 date "2008-05-20" @default.
• W2260696588 modified "2023-10-14" @default.
• W2260696588 title "Treating octogenarian and nonagenarian acute myeloid leukemia (AML) patients (pts): Predictive prognostic models" @default.
• W2260696588 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.20576" @default.
• W2260696588 hasPublicationYear "2008" @default.
• W2260696588 type Work @default.
• W2260696588 sameAs 2260696588 @default.
• W2260696588 citedByCount "0" @default.
• W2260696588 crossrefType "journal-article" @default.
• W2260696588 hasAuthorship W2260696588A5008341315 @default.
• W2260696588 hasAuthorship W2260696588A5010060503 @default.
• W2260696588 hasAuthorship W2260696588A5016601438 @default.
• W2260696588 hasAuthorship W2260696588A5025455280 @default.
• W2260696588 hasAuthorship W2260696588A5033926779 @default.
• W2260696588 hasAuthorship W2260696588A5039028985 @default.
• W2260696588 hasAuthorship W2260696588A5065404552 @default.
• W2260696588 hasAuthorship W2260696588A5066931842 @default.
• W2260696588 hasAuthorship W2260696588A5077133890 @default.
• W2260696588 hasAuthorship W2260696588A5080701625 @default.
• W2260696588 hasConcept C121608353 @default.
• W2260696588 hasConcept C126322002 @default.
• W2260696588 hasConcept C141071460 @default.
• W2260696588 hasConcept C2776907518 @default.
• W2260696588 hasConcept C2778488018 @default.
• W2260696588 hasConcept C2778729363 @default.
• W2260696588 hasConcept C2779159551 @default.
• W2260696588 hasConcept C3019063607 @default.
• W2260696588 hasConcept C71924100 @default.
• W2260696588 hasConcept C90924648 @default.
• W2260696588 hasConceptScore W2260696588C121608353 @default.
• W2260696588 hasConceptScore W2260696588C126322002 @default.
• W2260696588 hasConceptScore W2260696588C141071460 @default.
• W2260696588 hasConceptScore W2260696588C2776907518 @default.
• W2260696588 hasConceptScore W2260696588C2778488018 @default.
• W2260696588 hasConceptScore W2260696588C2778729363 @default.
• W2260696588 hasConceptScore W2260696588C2779159551 @default.
• W2260696588 hasConceptScore W2260696588C3019063607 @default.
• W2260696588 hasConceptScore W2260696588C71924100 @default.
• W2260696588 hasConceptScore W2260696588C90924648 @default.
• W2260696588 hasIssue "15_suppl" @default.
• W2260696588 hasLocation W22606965881 @default.
• W2260696588 hasOpenAccess W2260696588 @default.
• W2260696588 hasPrimaryLocation W22606965881 @default.
• W2260696588 hasRelatedWork W2054121888 @default.
• W2260696588 hasRelatedWork W2081454999 @default.
• W2260696588 hasRelatedWork W2152486433 @default.
• W2260696588 hasRelatedWork W2171773103 @default.
• W2260696588 hasRelatedWork W2242431621 @default.
• W2260696588 hasRelatedWork W2748753971 @default.
• W2260696588 hasRelatedWork W2913896224 @default.
• W2260696588 hasRelatedWork W2967257754 @default.
• W2260696588 hasRelatedWork W3032767437 @default.
• W2260696588 hasRelatedWork W85654011 @default.
• W2260696588 hasVolume "26" @default.
• W2260696588 isParatext "false" @default.
• W2260696588 isRetracted "false" @default.
• W2260696588 magId "2260696588" @default.
• W2260696588 workType "article" @default.