Matches in SemOpenAlex for { <https://semopenalex.org/work/W226074857> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W226074857 abstract "The chemical structure of streptomycin is reviewed. Results are reported from studies on the effects of streptidine on the frequency of radiation- induced chromosome aberrations in mouse Ehrlich ascites tumor cells. From resuits of this study it is concluded that the anti-radiation effect of streptomycin is wholly determined by the presence of its molecule of streptidine. Further investigations concerning the nature of the effect of streptidine showed that this substance contains reactive guanidino groups which are responsible for its beneficial influence in radiation injuries. The efficacy of substances of similar structure in reversing nuclear damage caused by irradiation was investigated. It was found that arginine is just as effective in combating radiation effects as streptomycin and streptidine. Guanidine, norvaline, and ornithine also exerted a favorable effect. It was concluded that the reversibility of radioinduced nuclear damage is due to substances containing a guanidino group, but not to guanidine itself. To be effective, the guanidino group must be linked with 4-hydroxycyclohexane in streptine or with the amino acid residue of arginine. Guanidine alone or the amino acid without guanidine did not have a protective effect. A possible relationship between the reduction of chromosome aberrations and desoxyribonucleic acid content is suggested. (C.H.)" @default.
- W226074857 created "2016-06-24" @default.
- W226074857 creator A5007487841 @default.
- W226074857 creator A5031740850 @default.
- W226074857 date "1960-01-01" @default.
- W226074857 modified "2023-09-27" @default.
- W226074857 title "CHEMICAL STRUCTURE OF STREPTOMYCIN AND THE CHANGE IN FREQUENCY OF NUCLEAR DAMAGE OF IRRADIATED MAMMALIAN CELLS" @default.
- W226074857 hasPublicationYear "1960" @default.
- W226074857 type Work @default.
- W226074857 sameAs 226074857 @default.
- W226074857 citedByCount "0" @default.
- W226074857 crossrefType "journal-article" @default.
- W226074857 hasAuthorship W226074857A5007487841 @default.
- W226074857 hasAuthorship W226074857A5031740850 @default.
- W226074857 hasConcept C111337013 @default.
- W226074857 hasConcept C121332964 @default.
- W226074857 hasConcept C12554922 @default.
- W226074857 hasConcept C185544564 @default.
- W226074857 hasConcept C185592680 @default.
- W226074857 hasConcept C2777468819 @default.
- W226074857 hasConcept C2779463914 @default.
- W226074857 hasConcept C515207424 @default.
- W226074857 hasConcept C55493867 @default.
- W226074857 hasConcept C86803240 @default.
- W226074857 hasConceptScore W226074857C111337013 @default.
- W226074857 hasConceptScore W226074857C121332964 @default.
- W226074857 hasConceptScore W226074857C12554922 @default.
- W226074857 hasConceptScore W226074857C185544564 @default.
- W226074857 hasConceptScore W226074857C185592680 @default.
- W226074857 hasConceptScore W226074857C2777468819 @default.
- W226074857 hasConceptScore W226074857C2779463914 @default.
- W226074857 hasConceptScore W226074857C515207424 @default.
- W226074857 hasConceptScore W226074857C55493867 @default.
- W226074857 hasConceptScore W226074857C86803240 @default.
- W226074857 hasLocation W2260748571 @default.
- W226074857 hasOpenAccess W226074857 @default.
- W226074857 hasPrimaryLocation W2260748571 @default.
- W226074857 hasRelatedWork W1482379902 @default.
- W226074857 hasRelatedWork W1504991889 @default.
- W226074857 hasRelatedWork W1527933039 @default.
- W226074857 hasRelatedWork W1528693378 @default.
- W226074857 hasRelatedWork W1765655209 @default.
- W226074857 hasRelatedWork W1926873045 @default.
- W226074857 hasRelatedWork W1973931147 @default.
- W226074857 hasRelatedWork W1999236391 @default.
- W226074857 hasRelatedWork W2004566935 @default.
- W226074857 hasRelatedWork W2014963036 @default.
- W226074857 hasRelatedWork W2016744448 @default.
- W226074857 hasRelatedWork W2024927510 @default.
- W226074857 hasRelatedWork W2081006969 @default.
- W226074857 hasRelatedWork W2151240678 @default.
- W226074857 hasRelatedWork W2271094859 @default.
- W226074857 hasRelatedWork W2288308110 @default.
- W226074857 hasRelatedWork W2334099327 @default.
- W226074857 hasRelatedWork W2375738718 @default.
- W226074857 hasRelatedWork W3025351386 @default.
- W226074857 hasRelatedWork W1580062404 @default.
- W226074857 isParatext "false" @default.
- W226074857 isRetracted "false" @default.
- W226074857 magId "226074857" @default.
- W226074857 workType "article" @default.