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- W2260775673 abstract "Purpose:This study was undertaken to observe the blood levels of IGF-I and 1,25- Vit. in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25- Vit. D3 metabolism in the presence of preeclampsia. Methods:Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and their newborns(normotensive group) were observed. IGF-I and 1,25- Vit. concentrations in maternal and umbilical cord blood were analysed. Results:Maternal and umbilical cord blood levels of IGF-I and 1,25- Vit. were significantly lower in the preeclampsia group than in the normotensive group. In the preeclampsia group, maternal and cord blood levels of IGF-I of small-for-gestational age newborns were significantly lower than those of appropriate-for-gestational age newborns. The birth weight and length of newborns correlated with IGF-I concentrations of maternal and umbilical cord blood in small-for-gestational age newborns of preeclampsia group. The correlation between IGF-I and 1,25- Vit. was significant in the umbilical cord blood of preeclampsia group, but only in appropriate-for-gestational age newborns. Conclusion:It is suggested that the lower level of IGF-I is the primary factor of intrauterine growth retardation in preeclampsia, and the effect of IGF-I on the metabolism of 1,25- Vit. is different according to the presence of preeclampsia and intrauterine fetal growth retardation. (Korean J Pediatr 2004;47:527-531)" @default.
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- W2260775673 date "2004-05-15" @default.
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- W2260775673 title "Effects of Insulin-like Growth Factor-I and 1,25- $(OH)_2$ Vitamin $D_3$ Concentration on Intrauterine Growth ofNewborns from Mothers with Preeclampsia" @default.
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