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• W2260801423 abstract "22183 Background: It was well-known, that 5-year survival (5YS) of non-small cell lung cancer (LC) patients (LCP) with stage IA (T1N0M0) with a tumor, diameter (D) less than 2cm reaches 100% after surgery while at D more than 2cm 5YS sharply falls. It was earlier proved, that it occurs because of phase transition (PT) “early-invasive LC” at the critical level of a LC cell population 4.189e+9 per human organism. Nevertheless, reaction of immunity at the human macrosystem, accompanying this PT is unknown. We have studied immune system of LCP with stage IA which D was less 2cm and 2.5–3cm. Methods: In trial (1986–2007) the data of consecutive 94 LC patients (LCP) after lobectomies (age=58.3±0.8 years; D=2.32±0.07 cm; m=80, f=14) with pathologic stage IA (T1N0M0) (squamous=36, adenocarcinoma=53, large cell=5; G1=32, G2=38, G3=24) were reviewed. D 0.5–2.0cm was in 48 (group A) and D=2.5–3.0cm - in 46 (group B).Variables selected for study were input levels of 64 immunity blood parameters, sex, age. Representativeness of samplings was reached by means of randomization based on unrepeated random selection. Logistic regression, clustering, discriminant analysis, neural networks computing, structural equation modeling, Monte Carlo and bootstrap simulation were used to determine any significant regularity. Results: 5YS was significantly superior in group A (100%) compared with group B (71.7%) (P<0.00045 by log-rank test). Logistic regression modeling displayed that PT significantly depended on: CD8+VV, CD8, CD16, B-cells (P=0.003–0.020). Neural networks computing, genetic algorithm selection and bootstrap simulation revealed relationships between PT and phagocytic number (rank=1), T-lymphocytes (2), IgA (3), NST-A2 (4), CD4 (5), index of thymus function (6), monocytes (7), CD8 (8), B-cells (9). It was discovered that cell ratio factors were of great value in PT: ratio between LC cells and neutrophils (rank=1), CD4+2H (2), CD8+VV (3), T-lymphocytes (4), CD1 (5), CDw26 (6), lymphocytes (7), eosinophils (8), monocytes (9). Conclusions: Correct recognition of PT was 71.3% by logistic regression (odds ratio=6.15), 92.6% by discriminant analysis and 100% by neural networks computing (area under ROC curve=1.0; error=1.99e-19). No significant financial relationships to disclose." @default.
• W2260801423 created "2016-06-24" @default.
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• W2260801423 date "2008-05-20" @default.
• W2260801423 modified "2023-09-23" @default.
• W2260801423 title "Synergetics, artificial intelligence, and complex system analysis in recognition of phase transition early-invasive lung cancer" @default.
• W2260801423 doi "https://doi.org/10.1200/jco.2008.26.15_suppl.22183" @default.
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