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• W2260810887 abstract "<b><i>Background/Aims:</i></b> Lipopolysaccharide (LPS) induces acute lung injury (ALI) through oxidative stress and inflammation. Naringenin exerts antioxidant and anti-inflammatory effects. The possible protective effect of naringenin was investigated against ALI induced by LPS in rats. <b><i>Methods:</i></b> Rats received a single injection of LPS (5 mg/kg, i.v.). Naringenin was given for 4 consecutive days, at 2 doses (50 and 100 mg/kg/day, p.o.), starting 3 days before LPS administration. <b><i>Results:</i></b> LPS significantly increased wet/dry lung weight ratio, malondialdehyde, nitric oxide (NO), interleukin-6, and myeloperoxidase activity in the lung tissues. Naringenin, particularly the higher dose, significantly ameliorated the LPS-induced changes in the measured parameters. Also, naringenin markedly reduced the histopathological lung tissue injury that resulted from LPS. Naringenin significantly decreased the LPS-induced expression of nuclear factor-&#954;B, inducible NO synthase, tumor necrosis factor-a, caspase-3, and significantly increased heat shock protein 70 expression in the lungs. <b><i>Conclusion:</i></b> Naringenin significantly protected against LPS-induced ALI in rats through its anti-inflammatory, antioxidant, antinitrosative, and antiapoptotic effects." @default.
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• W2260810887 date "2016-01-01" @default.
• W2260810887 modified "2023-10-18" @default.
• W2260810887 title "Protective Effect of Naringenin against Lipopolysaccharide-Induced Acute Lung Injury in Rats" @default.
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• W2260810887 doi "https://doi.org/10.1159/000444262" @default.
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