FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260897622> ?p ?o ?g. }

• W2260897622 endingPage "239" @default.
• W2260897622 startingPage "239" @default.
• W2260897622 abstract "Chronic obstructive pulmonary disease is characterized by emphysema, chronic bronchitis, and small airway remodeling. The alveolar destruction associated with emphysema cannot be repaired by current clinical practices. Stem cell therapy has been successfully used in animal models of cigarette smoke- and elastase-induced emphysema. However, the optimal dose of mesenchymal stem cells (MSCs) for the most effective therapy has not yet been determined. It is vital to determine the optimal dose of MSCs for clinical application in emphysema cases.In the present study, we evaluated the therapeutic effects of various doses of MSCs on elastase-induced emphysema in mice. When 3 different doses of MSCs were intravenously injected into mice treated with elastase, only 5×10(4) MSCs showed a significant effect on the emphysematous mouse lung. We also identified action mechanisms of MSCs based on apoptosis, lung regeneration, and protease/antiprotease imbalance.The MSCs were not related with caspase-3/7 dependent apoptosis. But activity of matrix metalloproteinase 9 increased by emphysematous lung was decreased by intravenously injected MSCs. Vascular endothelial growth factor were also increased in lung from MSC injected mice, as compared to un-injected mice.This is the first study on the optimal dose of MSCs as a therapeutic candidate. This data may provide important basic data for determining dosage in clinical application of MSCs in emphysema patients." @default.
• W2260897622 created "2016-06-24" @default.
• W2260897622 creator A5017327882 @default.
• W2260897622 creator A5030681976 @default.
• W2260897622 creator A5041792310 @default.
• W2260897622 creator A5047175737 @default.
• W2260897622 creator A5058515910 @default.
• W2260897622 creator A5058672000 @default.
• W2260897622 date "2015-01-01" @default.
• W2260897622 modified "2023-09-23" @default.
• W2260897622 title "The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema" @default.
• W2260897622 cites W1534731743 @default.
• W2260897622 cites W1970948263 @default.
• W2260897622 cites W1972171120 @default.
• W2260897622 cites W1977144038 @default.
• W2260897622 cites W1987119410 @default.
• W2260897622 cites W2003996125 @default.
• W2260897622 cites W2005962589 @default.
• W2260897622 cites W2024793853 @default.
• W2260897622 cites W2027597053 @default.
• W2260897622 cites W2030563465 @default.
• W2260897622 cites W2036348189 @default.
• W2260897622 cites W2047003893 @default.
• W2260897622 cites W2048704934 @default.
• W2260897622 cites W2057598532 @default.
• W2260897622 cites W2066549975 @default.
• W2260897622 cites W2069006548 @default.
• W2260897622 cites W2074084795 @default.
• W2260897622 cites W2090134402 @default.
• W2260897622 cites W2098734814 @default.
• W2260897622 cites W2104636056 @default.
• W2260897622 cites W2106629880 @default.
• W2260897622 cites W2108307444 @default.
• W2260897622 cites W2120508636 @default.
• W2260897622 cites W2131566159 @default.
• W2260897622 cites W2142724633 @default.
• W2260897622 cites W2144613920 @default.
• W2260897622 cites W2147387850 @default.
• W2260897622 cites W2162863647 @default.
• W2260897622 doi "https://doi.org/10.4046/trd.2015.78.3.239" @default.
• W2260897622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4499592" @default.
• W2260897622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26175778" @default.
• W2260897622 hasPublicationYear "2015" @default.
• W2260897622 type Work @default.
• W2260897622 sameAs 2260897622 @default.
• W2260897622 citedByCount "29" @default.
• W2260897622 countsByYear W22608976222016 @default.
• W2260897622 countsByYear W22608976222017 @default.
• W2260897622 countsByYear W22608976222018 @default.
• W2260897622 countsByYear W22608976222019 @default.
• W2260897622 countsByYear W22608976222020 @default.
• W2260897622 countsByYear W22608976222021 @default.
• W2260897622 countsByYear W22608976222022 @default.
• W2260897622 countsByYear W22608976222023 @default.
• W2260897622 crossrefType "journal-article" @default.
• W2260897622 hasAuthorship W2260897622A5017327882 @default.
• W2260897622 hasAuthorship W2260897622A5030681976 @default.
• W2260897622 hasAuthorship W2260897622A5041792310 @default.
• W2260897622 hasAuthorship W2260897622A5047175737 @default.
• W2260897622 hasAuthorship W2260897622A5058515910 @default.
• W2260897622 hasAuthorship W2260897622A5058672000 @default.
• W2260897622 hasBestOaLocation W22608976221 @default.
• W2260897622 hasConcept C126322002 @default.
• W2260897622 hasConcept C142724271 @default.
• W2260897622 hasConcept C181199279 @default.
• W2260897622 hasConcept C198826908 @default.
• W2260897622 hasConcept C203014093 @default.
• W2260897622 hasConcept C2776317360 @default.
• W2260897622 hasConcept C2776914184 @default.
• W2260897622 hasConcept C2777714996 @default.
• W2260897622 hasConcept C2781044401 @default.
• W2260897622 hasConcept C2992694001 @default.
• W2260897622 hasConcept C502942594 @default.
• W2260897622 hasConcept C55493867 @default.
• W2260897622 hasConcept C71924100 @default.
• W2260897622 hasConcept C86803240 @default.
• W2260897622 hasConcept C98274493 @default.
• W2260897622 hasConceptScore W2260897622C126322002 @default.
• W2260897622 hasConceptScore W2260897622C142724271 @default.
• W2260897622 hasConceptScore W2260897622C181199279 @default.
• W2260897622 hasConceptScore W2260897622C198826908 @default.
• W2260897622 hasConceptScore W2260897622C203014093 @default.
• W2260897622 hasConceptScore W2260897622C2776317360 @default.
• W2260897622 hasConceptScore W2260897622C2776914184 @default.
• W2260897622 hasConceptScore W2260897622C2777714996 @default.
• W2260897622 hasConceptScore W2260897622C2781044401 @default.
• W2260897622 hasConceptScore W2260897622C2992694001 @default.
• W2260897622 hasConceptScore W2260897622C502942594 @default.
• W2260897622 hasConceptScore W2260897622C55493867 @default.
• W2260897622 hasConceptScore W2260897622C71924100 @default.
• W2260897622 hasConceptScore W2260897622C86803240 @default.
• W2260897622 hasConceptScore W2260897622C98274493 @default.
• W2260897622 hasFunder F4320322034 @default.
• W2260897622 hasIssue "3" @default.
• W2260897622 hasLocation W22608976221 @default.
• W2260897622 hasLocation W22608976222 @default.
• W2260897622 hasLocation W22608976223 @default.
• W2260897622 hasOpenAccess W2260897622 @default.

• next