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- W2260900153 abstract ": Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001).Conclusion : voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes." @default.
- W2260900153 created "2016-06-24" @default.
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- W2260900153 date "2013-05-01" @default.
- W2260900153 modified "2023-09-27" @default.
- W2260900153 title "The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats" @default.
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