FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2260997035> ?p ?o ?g. }

• W2260997035 endingPage "672" @default.
• W2260997035 startingPage "661" @default.
• W2260997035 abstract "SCUBE1 (S1), a secreted and membrane-bound glycoprotein, has a modular protein structure composed of an N-terminal signal peptide sequence followed by nine epidermal growth factor (EGF)-like repeats, a spacer region and three cysteine-rich (CR) motifs with multiple potential N-linked glycosylation sites, and one CUB domain at the C-terminus. Soluble S1 is a biomarker of platelet activation but an active participant of thrombosis via its adhesive EGF-like repeats, whereas its membrane-associated form acts as a bone morphogenetic protein (BMP) co-receptor in promoting BMP signal activity. However, the mechanism responsible for the membrane tethering and the biological importance of N-glycosylation of S1 remain largely unknown. In the present study, molecular mapping analysis identified a polycationic segment (amino acids 501–550) in the spacer region required for its membrane tethering via electrostatic interactions possibly with the anionic heparan sulfate proteoglycans. Furthermore, deglycosylation by peptide N-glycosidase F treatment revealed that N-glycans within the CR motif are essential for membrane recruitment through lectin-mediated surface retention. Injection of mRNA encoding zebrafish wild-type but not N-glycan-deficient scube1 restores the expression of haematopoietic and erythroid markers (scl and gata1) in scube1-knockdown embryos. We describe novel mechanisms in targeting S1 to the plasma membrane and demonstrate that N-glycans are required for S1 functions during primitive haematopoiesis in zebrafish." @default.
• W2260997035 created "2016-06-24" @default.
• W2260997035 creator A5014232912 @default.
• W2260997035 creator A5071924282 @default.
• W2260997035 creator A5076555782 @default.
• W2260997035 date "2016-02-24" @default.
• W2260997035 modified "2023-10-16" @default.
• W2260997035 title "Electrostatics and N-glycan-mediated membrane tethering of SCUBE1 is critical for promoting bone morphogenetic protein signalling" @default.
• W2260997035 cites W1564861448 @default.
• W2260997035 cites W1967429840 @default.
• W2260997035 cites W1969608698 @default.
• W2260997035 cites W1971935872 @default.
• W2260997035 cites W1988013407 @default.
• W2260997035 cites W1994303245 @default.
• W2260997035 cites W2013492079 @default.
• W2260997035 cites W2019038077 @default.
• W2260997035 cites W2019592403 @default.
• W2260997035 cites W2022170395 @default.
• W2260997035 cites W2026905611 @default.
• W2260997035 cites W2032935853 @default.
• W2260997035 cites W2033199493 @default.
• W2260997035 cites W2033777508 @default.
• W2260997035 cites W2034842916 @default.
• W2260997035 cites W2035770797 @default.
• W2260997035 cites W2039404256 @default.
• W2260997035 cites W2053188090 @default.
• W2260997035 cites W2059496673 @default.
• W2260997035 cites W2062930347 @default.
• W2260997035 cites W2064754325 @default.
• W2260997035 cites W2066915390 @default.
• W2260997035 cites W2069863445 @default.
• W2260997035 cites W2078267991 @default.
• W2260997035 cites W2079690512 @default.
• W2260997035 cites W2080404107 @default.
• W2260997035 cites W2080867464 @default.
• W2260997035 cites W2083163414 @default.
• W2260997035 cites W2086023112 @default.
• W2260997035 cites W2097084884 @default.
• W2260997035 cites W2107760509 @default.
• W2260997035 cites W2110832914 @default.
• W2260997035 cites W2124445995 @default.
• W2260997035 cites W2124916682 @default.
• W2260997035 cites W2132210313 @default.
• W2260997035 cites W2136642285 @default.
• W2260997035 cites W2148731673 @default.
• W2260997035 cites W2164060627 @default.
• W2260997035 cites W2165562833 @default.
• W2260997035 doi "https://doi.org/10.1042/bj20151041" @default.
• W2260997035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26699903" @default.
• W2260997035 hasPublicationYear "2016" @default.
• W2260997035 type Work @default.
• W2260997035 sameAs 2260997035 @default.
• W2260997035 citedByCount "13" @default.
• W2260997035 countsByYear W22609970352016 @default.
• W2260997035 countsByYear W22609970352017 @default.
• W2260997035 countsByYear W22609970352018 @default.
• W2260997035 countsByYear W22609970352019 @default.
• W2260997035 countsByYear W22609970352021 @default.
• W2260997035 countsByYear W22609970352022 @default.
• W2260997035 countsByYear W22609970352023 @default.
• W2260997035 crossrefType "journal-article" @default.
• W2260997035 hasAuthorship W2260997035A5014232912 @default.
• W2260997035 hasAuthorship W2260997035A5071924282 @default.
• W2260997035 hasAuthorship W2260997035A5076555782 @default.
• W2260997035 hasConcept C104317684 @default.
• W2260997035 hasConcept C10858879 @default.
• W2260997035 hasConcept C153911025 @default.
• W2260997035 hasConcept C167625842 @default.
• W2260997035 hasConcept C185592680 @default.
• W2260997035 hasConcept C2777313579 @default.
• W2260997035 hasConcept C31507581 @default.
• W2260997035 hasConcept C55493867 @default.
• W2260997035 hasConcept C86803240 @default.
• W2260997035 hasConcept C95444343 @default.
• W2260997035 hasConceptScore W2260997035C104317684 @default.
• W2260997035 hasConceptScore W2260997035C10858879 @default.
• W2260997035 hasConceptScore W2260997035C153911025 @default.
• W2260997035 hasConceptScore W2260997035C167625842 @default.
• W2260997035 hasConceptScore W2260997035C185592680 @default.
• W2260997035 hasConceptScore W2260997035C2777313579 @default.
• W2260997035 hasConceptScore W2260997035C31507581 @default.
• W2260997035 hasConceptScore W2260997035C55493867 @default.
• W2260997035 hasConceptScore W2260997035C86803240 @default.
• W2260997035 hasConceptScore W2260997035C95444343 @default.
• W2260997035 hasIssue "5" @default.
• W2260997035 hasLocation W22609970351 @default.
• W2260997035 hasLocation W22609970352 @default.
• W2260997035 hasOpenAccess W2260997035 @default.
• W2260997035 hasPrimaryLocation W22609970351 @default.
• W2260997035 hasRelatedWork W1536386118 @default.
• W2260997035 hasRelatedWork W1917535562 @default.
• W2260997035 hasRelatedWork W2013741645 @default.
• W2260997035 hasRelatedWork W2023556160 @default.
• W2260997035 hasRelatedWork W2040762413 @default.
• W2260997035 hasRelatedWork W2072604958 @default.
• W2260997035 hasRelatedWork W2075613798 @default.
• W2260997035 hasRelatedWork W2092029216 @default.
• W2260997035 hasRelatedWork W2148913876 @default.

• next