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- W2261068668 endingPage "5802" @default.
- W2261068668 startingPage "5794" @default.
- W2261068668 abstract "The functionalization of aliphatic and aromatic C–H bonds has remained a priority in transition-metal catalysis for the last few decades. N-heterocyclic carbenes (NHCs) have very recently been proven as an effective organocatalytic alternative toward site-selective sp3 β-C–H bond functionalization in aliphatic esters and related compounds. We have employed modern density functional theory computations to provide the first mechanistic insights into this entirely new form of reactivity of NHCs, leading to β-C–H bond activation. NHC-catalyzed coupling between hydrazone and β-phenyl propionate leading to a γ-lactam bearing two chiral centers is reported. An interesting two-step mechanistic cascade that helps surmount the high bond dissociation energy of an otherwise inert β-C–H bond is identified. An initial addition–elimination at the ester group installs the chiral triazolium NHC to the substrate. The deprotonation of the α-C–H by the departing phenoxide first furnishes an α-enolate intermediate. A concerte..." @default.
- W2261068668 created "2016-06-24" @default.
- W2261068668 creator A5018528585 @default.
- W2261068668 creator A5051883888 @default.
- W2261068668 date "2015-09-01" @default.
- W2261068668 modified "2023-09-26" @default.
- W2261068668 title "Mechanistic Studies on Stereoselective Organocatalytic Direct β-C–H Activation in an Aliphatic Chain by Chiral N-Heterocyclic Carbenes" @default.
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