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- W2261120851 abstract "This study aimed to: assess the mucosal alterations of the larynx and hypopharynx typical for mucopolysaccharidoses, in a standardised manner; compare the severity in different subtypes of mucopolysaccharidoses; and monitor the effect of an enzyme replacement therapy.A classification for mucosal alterations of the larynx and hypopharynx was developed and utilised in 55 patients with mucopolysaccharidoses. Fifteen patients who started treatment with enzyme replacement therapy were followed longitudinally.The most severe alterations were seen in the posterior region of the larynx and the arytenoids, and in the region of the false vocal folds. The alterations were most severe in patients with mucopolysaccharidosis II. No clear trend was observed in the patients who received enzyme replacement therapy.Quantification of mucosal alterations of the hypopharynx and larynx in mucopolysaccharidoses patients can provide information about the disease's natural process and about the efficacy of enzyme replacement therapy." @default.
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- W2261120851 date "2015-12-17" @default.
- W2261120851 modified "2023-09-27" @default.
- W2261120851 title "Alterations of mucosa of the larynx and hypopharynx in patients with mucopolysaccharidoses" @default.
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- W2261120851 doi "https://doi.org/10.1017/s0022215115003357" @default.
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