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- W2261121833 abstract "Scientists interested in exploring fundamental mechanisms of aging need to judiciously choose animal models of aging most appropriate for their area of research. Similarly, great care must be taken when using animal models for the study of disease processes that tend to occur in late life. The establishment of funding agencies devoted to aging research (e.g., U.S. National Institute on Aging [NIA] in 1974) and a growing general interest in aging have led to an unprecedented increase in the use of aging models and in resulting publications. Although researchers are now able to choose from a broad variety of vertebrate and invertebrate models, most such research is still conducted using a very limited number of rat or mouse strains. Because no one single species or strain is optimal for all aging questions and studies, care must be given to the choice of the most appropriate animal aging model. Moreover, other animal-related issues, such as the presence of confounding disease, genetic background, diet, housing, husbandry, microbial status, and exercise, all can greatly influence experimental results. Thus, when designing aging studies, these factors must be given the same considerations as is the determination of an outcome measure of primary interest to investigators. Fortunately, although important issues still remain unresolved, researchers are now able to base their decisions on a reasonable body of experience and knowledge." @default.
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- W2261121833 date "2014-01-01" @default.
- W2261121833 modified "2023-09-27" @default.
- W2261121833 title "Animal Models for Aging" @default.
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- W2261121833 doi "https://doi.org/10.1016/b978-0-12-801238-3.03853-8" @default.
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