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• W2261147245 abstract "Crude oil (CO) is a substance trado-medically used within some rural population as an antidote to poisoning and a cure for various gastro-intestinal disturbances among others. The ingestion of crude oil either orally or through polluted marine species represents a pathway for the delivery of potential toxicants to the human system. The study, therefore, analysed the effects of bonny light crude oil on the activities of anti-oxidative enzymes [superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST)] and the concentration of total proteins (TP). The results show that SOD activity was significantly lower (p 0.05) between the SOD activity of the rats treated with 3 ml of crude oil/kg b.w (1.25 ± 0.27) and that of the control rats. CAT specific activity in the rats of the control group (5.5 ± 3.2x10 -3 ) was lower than that of the rats administered 3 ml of crude oil/kg b.w (6.2±3.4 x 10 -3 ), 6 ml of crude oil/kg b.w (7.5±4.8 x 10 -3 ) and 9 ml of crude oil/kg b.w (12.5 ± 8.3 x 10 -3 ); although the mean differences were not statistically significant (p>0.05). GST specific activity was higher in the rats of the crude oil-untreated group (88.6 ± 136.3 x 10 -3 ) compared to the rats of the group treated with 3 ml of crude oil/kg b.w (82.7 ± 32.3 x 10 -3 ), 6 ml of crude oil/kg b.w (26.0 ± 19.5 x 10 -3 ) and 9 ml of crude oil/kg b.w (25.4 ± 21.2 x 10 -3 ). Nevertheless, the mean differences were still not statistically significant (p>0.05). Total proteins concentration was significantly lower (p<0.05) in the rats given 9 ml of crude oil/kg b.w (0.33±0.08) compared to that of the control rats (0.05±0.02). In connection with the above results, the crude oil at high dose was found to have oxidative stress-inducing potential and hence, warrants that its use be discouraged or replaced with other less or non-toxic agents with similar therapeutic values as it. Key words: Crude oil, trado-medically, bonny light, anti-oxidative enzymes and total proteins." @default.
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• W2261147245 date "2012-01-01" @default.
• W2261147245 modified "2023-09-23" @default.
• W2261147245 title "Effects of bonny light crude oil on anti-oxidative enzymes and total proteins in Wistar rats" @default.
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