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• W2261214933 abstract "Arabidopsis thaliana is an established model plant system for studying plantpathogeninteractions. The knowledge garnered from examining the mechanism ofinduced disease resistance in this model system can be applied to eliminate the cost anddanger associated with current means of crop protection.A specific defense pathway, known as systemic acquired resistance (SAR),involves whole plant protection from a wide variety of bacterial, viral and fungalpathogens and remains induced weeks to months after being triggered. The ability ofArabidopsis to mount SAR depends on the accumulation of salicylic acid (SA), the NPRI(non-expressor of pathogenesis related gene 1) protein and the expression of a subset ofpathogenesis related (PR) genes. NPRI exerts its effect in this pathway throughinteraction with a closely related class of bZIP transcription factors known as TGAfactors, which are named for their recognition of the cognate DNA motif TGACG.We have discovered that one of these transcription factors, TGA2, behaves as arepressor in unchallenged Arabidopsis and acts to repress NPRI-dependent activation ofPRJ. TGA1, which bears moderate sequence similarity to TGA2, acts as a transcriptionalactivator in unchallenged Arabidopsis, however the significance of this activity isJunclear. Once SAR has been induced, TGAI and TGA2 interact with NPRI to formcomplexes that are capable of activating transcription. Curiously, although TGAI iscapable of transactivating, the ability of the TGAI-NPRI complex to activatetranscription results from a novel transactivation domain in NPRI. This transactivationdomain, which depends on the oxidation of cysteines 521 and 529, is also responsible forthe transactivation ability of the TGA2-NPRI complex. Although the exact mechanism preventing TGA2-NPRI interaction inunchallenged Arabidopsis is unclear, the regulation of TGAI-NPRI interaction is basedon the redox status of cysteines 260 and 266 in TGAl. We determined that aglutaredoxin, which is an enzyme capable of regulating a protein's redox status, interactswith the reduced form of TGAI and this interaction results .in the glutathionylation ofTGAI and a loss of interaction with NPRl.Taken together, these results expand our understanding of how TGA transcriptionfactors and NPRI behave to regulate events and gene expression during SAR.Furthermore, the regulation of the behavior of both TGAI and NPRI by their redoxstatus and the involvement of a glutaredoxin in modulating TGAI-NPRI interactionsuggests the redox regulation of proteins is a general mechanism implemented in SAR." @default.
• W2261214933 created "2016-06-24" @default.
• W2261214933 creator A5051212846 @default.
• W2261214933 date "2012-07-31" @default.
• W2261214933 modified "2023-09-24" @default.
• W2261214933 title "Regulation of Systemic Acquired Resistance through the Interaction of Arabidopsis thaliana Transcription factors TGAI and TGA2 with NPRI" @default.
• W2261214933 cites W1207326270 @default.
• W2261214933 cites W132091025 @default.
• W2261214933 cites W1499156123 @default.
• W2261214933 cites W1500853161 @default.
• W2261214933 cites W1508668263 @default.
• W2261214933 cites W1512338554 @default.
• W2261214933 cites W1522099221 @default.
• W2261214933 cites W1538998519 @default.
• W2261214933 cites W1541173472 @default.
• W2261214933 cites W1554423718 @default.
• W2261214933 cites W1557768505 @default.
• W2261214933 cites W1568652712 @default.
• W2261214933 cites W1575028964 @default.
• W2261214933 cites W1588544668 @default.
• W2261214933 cites W1592746453 @default.
• W2261214933 cites W1593932996 @default.
• W2261214933 cites W1603513572 @default.
• W2261214933 cites W1628783271 @default.
• W2261214933 cites W1632044028 @default.
• W2261214933 cites W1648085736 @default.
• W2261214933 cites W1714655073 @default.
• W2261214933 cites W1796479192 @default.
• W2261214933 cites W1884528635 @default.
• W2261214933 cites W1920908115 @default.
• W2261214933 cites W1932728046 @default.
• W2261214933 cites W1942665378 @default.
• W2261214933 cites W1951642541 @default.
• W2261214933 cites W1963846053 @default.
• W2261214933 cites W1966975589 @default.
• W2261214933 cites W1968202857 @default.
• W2261214933 cites W1968648023 @default.
• W2261214933 cites W1971131877 @default.
• W2261214933 cites W1971204359 @default.
• W2261214933 cites W1971368740 @default.
• W2261214933 cites W1973076997 @default.
• W2261214933 cites W1973554224 @default.
• W2261214933 cites W1974129214 @default.
• W2261214933 cites W1974938117 @default.
• W2261214933 cites W1977345158 @default.
• W2261214933 cites W1980168194 @default.
• W2261214933 cites W1981811610 @default.
• W2261214933 cites W1982756681 @default.
• W2261214933 cites W1984675704 @default.
• W2261214933 cites W1986191025 @default.
• W2261214933 cites W1986207557 @default.
• W2261214933 cites W1987003587 @default.
• W2261214933 cites W1987478705 @default.
• W2261214933 cites W1988580531 @default.
• W2261214933 cites W1988622364 @default.
• W2261214933 cites W1988726352 @default.
• W2261214933 cites W1991251241 @default.
• W2261214933 cites W1991628500 @default.
• W2261214933 cites W1993035828 @default.
• W2261214933 cites W1995170771 @default.
• W2261214933 cites W1995444885 @default.
• W2261214933 cites W1997242330 @default.
• W2261214933 cites W1997767982 @default.
• W2261214933 cites W1999320089 @default.
• W2261214933 cites W1999869029 @default.
• W2261214933 cites W2000711592 @default.
• W2261214933 cites W2001569178 @default.
• W2261214933 cites W2001586790 @default.
• W2261214933 cites W2002794726 @default.
• W2261214933 cites W2002831009 @default.
• W2261214933 cites W2003148884 @default.
• W2261214933 cites W2003954743 @default.
• W2261214933 cites W2004546324 @default.
• W2261214933 cites W2004863729 @default.
• W2261214933 cites W2006688297 @default.
• W2261214933 cites W2006997720 @default.
• W2261214933 cites W2008049923 @default.
• W2261214933 cites W2008251750 @default.
• W2261214933 cites W2008527118 @default.
• W2261214933 cites W2010094123 @default.
• W2261214933 cites W2010590542 @default.
• W2261214933 cites W2011171601 @default.
• W2261214933 cites W2014688186 @default.
• W2261214933 cites W2015642465 @default.
• W2261214933 cites W2017162186 @default.
• W2261214933 cites W2017810508 @default.
• W2261214933 cites W2020008107 @default.
• W2261214933 cites W2020538411 @default.
• W2261214933 cites W2021521164 @default.
• W2261214933 cites W2021731617 @default.
• W2261214933 cites W2023183725 @default.
• W2261214933 cites W2024556021 @default.
• W2261214933 cites W2025532989 @default.
• W2261214933 cites W2027251850 @default.
• W2261214933 cites W2028872099 @default.
• W2261214933 cites W2029949690 @default.
• W2261214933 cites W2030034707 @default.
• W2261214933 cites W2031236247 @default.
• W2261214933 cites W2033993360 @default.
• W2261214933 cites W2034346083 @default.

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