Matches in SemOpenAlex for { <https://semopenalex.org/work/W2261220172> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2261220172 endingPage "30" @default.
- W2261220172 startingPage "25" @default.
- W2261220172 abstract "Molecular chaperones, commonly known as heat shock proteins (HSPs), are essential for mammalian cells to maintain homeostasis. HSPs may interact with diverse co-chaperones to induce an ATPase-coupled structural change in the client proteins and to regulate critical signaling networks. Many HSP client proteins are known to play a key role in human cancers, and strategy targeting HSP has been developed as an important approach for therapeutic application in human cancers. The human timorous imaginal disc 1 (Tid1) protein, a DnaJ co-chaperone, is a tumor suppressor and is known to promote ubiquitin-mediated degradation of oncogenic kinases. Recent studies from our group have shown that Tid1 functions as a tumor suppressor through affecting ErbB-related signaling. In this article, the recent findings on the function and expression of Tid1 in breast cancer, head and neck cancer, and lung adenocarcinoma will be reviewed. In addition, the potential application of Tid1 as a novel target for HSP directed therapy will be discussed." @default.
- W2261220172 created "2016-06-24" @default.
- W2261220172 creator A5087684718 @default.
- W2261220172 date "2012-06-01" @default.
- W2261220172 modified "2023-09-23" @default.
- W2261220172 title "Tid1 as a Novel Target for HSP-Directed Therapy in Human Cancer" @default.
- W2261220172 doi "https://doi.org/10.6192/cgust.2012.6.16.3" @default.
- W2261220172 hasPublicationYear "2012" @default.
- W2261220172 type Work @default.
- W2261220172 sameAs 2261220172 @default.
- W2261220172 citedByCount "0" @default.
- W2261220172 crossrefType "journal-article" @default.
- W2261220172 hasAuthorship W2261220172A5087684718 @default.
- W2261220172 hasConcept C104317684 @default.
- W2261220172 hasConcept C121608353 @default.
- W2261220172 hasConcept C142724271 @default.
- W2261220172 hasConcept C179185449 @default.
- W2261220172 hasConcept C184235292 @default.
- W2261220172 hasConcept C205260736 @default.
- W2261220172 hasConcept C25602115 @default.
- W2261220172 hasConcept C2775932338 @default.
- W2261220172 hasConcept C2775962898 @default.
- W2261220172 hasConcept C502942594 @default.
- W2261220172 hasConcept C54355233 @default.
- W2261220172 hasConcept C62478195 @default.
- W2261220172 hasConcept C71924100 @default.
- W2261220172 hasConcept C86803240 @default.
- W2261220172 hasConcept C95444343 @default.
- W2261220172 hasConceptScore W2261220172C104317684 @default.
- W2261220172 hasConceptScore W2261220172C121608353 @default.
- W2261220172 hasConceptScore W2261220172C142724271 @default.
- W2261220172 hasConceptScore W2261220172C179185449 @default.
- W2261220172 hasConceptScore W2261220172C184235292 @default.
- W2261220172 hasConceptScore W2261220172C205260736 @default.
- W2261220172 hasConceptScore W2261220172C25602115 @default.
- W2261220172 hasConceptScore W2261220172C2775932338 @default.
- W2261220172 hasConceptScore W2261220172C2775962898 @default.
- W2261220172 hasConceptScore W2261220172C502942594 @default.
- W2261220172 hasConceptScore W2261220172C54355233 @default.
- W2261220172 hasConceptScore W2261220172C62478195 @default.
- W2261220172 hasConceptScore W2261220172C71924100 @default.
- W2261220172 hasConceptScore W2261220172C86803240 @default.
- W2261220172 hasConceptScore W2261220172C95444343 @default.
- W2261220172 hasIssue "16" @default.
- W2261220172 hasLocation W22612201721 @default.
- W2261220172 hasOpenAccess W2261220172 @default.
- W2261220172 hasPrimaryLocation W22612201721 @default.
- W2261220172 hasRelatedWork W1505201570 @default.
- W2261220172 hasRelatedWork W2006148642 @default.
- W2261220172 hasRelatedWork W2026972184 @default.
- W2261220172 hasRelatedWork W2033106731 @default.
- W2261220172 hasRelatedWork W2060095764 @default.
- W2261220172 hasRelatedWork W2099460892 @default.
- W2261220172 hasRelatedWork W2100508842 @default.
- W2261220172 hasRelatedWork W2100647791 @default.
- W2261220172 hasRelatedWork W2114507389 @default.
- W2261220172 hasRelatedWork W2185686976 @default.
- W2261220172 hasRelatedWork W2567717198 @default.
- W2261220172 hasRelatedWork W2755428803 @default.
- W2261220172 hasRelatedWork W2810135452 @default.
- W2261220172 hasRelatedWork W2810304076 @default.
- W2261220172 hasRelatedWork W2958213715 @default.
- W2261220172 hasRelatedWork W2995358496 @default.
- W2261220172 hasRelatedWork W2997805606 @default.
- W2261220172 hasRelatedWork W3010628223 @default.
- W2261220172 hasRelatedWork W3016219863 @default.
- W2261220172 hasRelatedWork W3153667166 @default.
- W2261220172 isParatext "false" @default.
- W2261220172 isRetracted "false" @default.
- W2261220172 magId "2261220172" @default.
- W2261220172 workType "article" @default.