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• W2261221201 abstract "In the last decade, the integration of molecular approaches including transcriptome and miRNome analyses uncovered pathological mechanisms involved in the progression of diabetic nephropathy (DN). Using these techniques, molecular marker candidates [both messenger RNA (mRNA) and miRNA] have also been identified which may enable the characterization of patients at high risk for progression to end-stage renal disease. The results of such studies are urgently needed for a molecular definition of DN and for targeted treatment to improve patient care. The heterogeneity of kidney tissue and the minute amounts of RNA isolated from renal biopsies remain a challenge for omics-studies. Nevertheless, several studies have succeeded in the identification of RNA expression signatures in patients with diabetes and kidney disease. These studies show a reduced expression of growth factors such as VEGF and EGF, and an increased expression of matrix components and matrix-modulating enzymes, an activation of specific NF-κB modules, inflammatory pathways and the complement system. microRNAs are involved in the fine-tuning of mRNA abundance by binding to the 3' untranslated region of a target mRNA, which leads in most cases to translational repression or mRNA cleavage and a decrease in protein output. Here, we review the platforms used for miRNA expression profiling and ways to predict miRNA targets and functions. Several miRNAs have been shown to be involved in the pathogenesis of DN (e.g. miR-21, miR-192, miR-215, miR-216a, miR-29, let-7, miR-25, miR-93, etc.). Functional studies provide evidence that miRNAs are not only diagnostic tools but also represent potential therapeutic targets in DN." @default.
• W2261221201 created "2016-06-24" @default.
• W2261221201 creator A5043086600 @default.
• W2261221201 creator A5052134087 @default.
• W2261221201 creator A5062730954 @default.
• W2261221201 creator A5086580140 @default.
• W2261221201 date "2015-07-24" @default.
• W2261221201 modified "2023-10-18" @default.
• W2261221201 title "RNA expression signatures and posttranscriptional regulation in diabetic nephropathy" @default.
• W2261221201 cites W1492748176 @default.
• W2261221201 cites W1528549949 @default.
• W2261221201 cites W1963952972 @default.
• W2261221201 cites W1965934436 @default.
• W2261221201 cites W1967550939 @default.
• W2261221201 cites W1972925702 @default.
• W2261221201 cites W1974254202 @default.
• W2261221201 cites W1979322303 @default.
• W2261221201 cites W1982810690 @default.
• W2261221201 cites W1987922761 @default.
• W2261221201 cites W1989595554 @default.
• W2261221201 cites W1995852794 @default.
• W2261221201 cites W2000491596 @default.
• W2261221201 cites W2000579954 @default.
• W2261221201 cites W2000893559 @default.
• W2261221201 cites W2006079840 @default.
• W2261221201 cites W2009132304 @default.
• W2261221201 cites W2009938201 @default.
• W2261221201 cites W2016969435 @default.
• W2261221201 cites W2022617421 @default.
• W2261221201 cites W2026570544 @default.
• W2261221201 cites W2030339637 @default.
• W2261221201 cites W2031266182 @default.
• W2261221201 cites W2033457930 @default.
• W2261221201 cites W2041233550 @default.
• W2261221201 cites W2045991006 @default.
• W2261221201 cites W2048178760 @default.
• W2261221201 cites W2049435756 @default.
• W2261221201 cites W2050271685 @default.
• W2261221201 cites W2050869737 @default.
• W2261221201 cites W2051911149 @default.
• W2261221201 cites W2053293102 @default.
• W2261221201 cites W2053490054 @default.
• W2261221201 cites W2063579084 @default.
• W2261221201 cites W2070633280 @default.
• W2261221201 cites W2071271349 @default.
• W2261221201 cites W2077755631 @default.
• W2261221201 cites W2080018357 @default.
• W2261221201 cites W2082644193 @default.
• W2261221201 cites W2083381199 @default.
• W2261221201 cites W2089142809 @default.
• W2261221201 cites W2089157622 @default.
• W2261221201 cites W2091613784 @default.
• W2261221201 cites W2097628596 @default.
• W2261221201 cites W2099017523 @default.
• W2261221201 cites W2110378853 @default.
• W2261221201 cites W2111848990 @default.
• W2261221201 cites W2113881372 @default.
• W2261221201 cites W2115280144 @default.
• W2261221201 cites W2116236561 @default.
• W2261221201 cites W2116799486 @default.
• W2261221201 cites W2119591380 @default.
• W2261221201 cites W2120456037 @default.
• W2261221201 cites W2121014368 @default.
• W2261221201 cites W2121596834 @default.
• W2261221201 cites W2126140528 @default.
• W2261221201 cites W2127367545 @default.
• W2261221201 cites W2127522557 @default.
• W2261221201 cites W2128160632 @default.
• W2261221201 cites W2128219894 @default.
• W2261221201 cites W2128731054 @default.
• W2261221201 cites W2128768066 @default.
• W2261221201 cites W2130979840 @default.
• W2261221201 cites W2131349854 @default.
• W2261221201 cites W2133992949 @default.
• W2261221201 cites W2136490577 @default.
• W2261221201 cites W2138884188 @default.
• W2261221201 cites W2142878546 @default.
• W2261221201 cites W2144774384 @default.
• W2261221201 cites W2146363970 @default.
• W2261221201 cites W2148362020 @default.
• W2261221201 cites W2148652246 @default.
• W2261221201 cites W2156232364 @default.
• W2261221201 cites W2159857693 @default.
• W2261221201 cites W2160019957 @default.
• W2261221201 cites W2160333540 @default.
• W2261221201 cites W2166240615 @default.
• W2261221201 cites W2166882556 @default.
• W2261221201 cites W2170446948 @default.
• W2261221201 cites W2171845476 @default.
• W2261221201 cites W4234713026 @default.
• W2261221201 cites W4237473415 @default.
• W2261221201 doi "https://doi.org/10.1093/ndt/gfv079" @default.
• W2261221201 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26209736" @default.
• W2261221201 hasPublicationYear "2015" @default.
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