FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2261232513> ?p ?o ?g. }

• W2261232513 endingPage "e0147778" @default.
• W2261232513 startingPage "e0147778" @default.
• W2261232513 abstract "Recently, academic studies suggest that global growth of airway allergic disease has a close association with dietary changes including reduced consumption of fiber. Therefore, appropriate dietary fiber supplementation might be potential to prevent airway allergic disease (AAD).We investigated whether dietary fiber intake suppressed the induction of AAD and tried to elucidate the possible underlying mechanisms.The control mice and AAD model mice fed with 4% standard-fiber chow, while low-fiber group of mice fed with a 1.75% low-fiber chow. The two fiber-intervened groups including mice, apart from a standard-fiber diet, were also intragastric (i.g.) administrated daily with poorly fermentable cellulose or readily fermentable pectin (0.4% of daily body weight), respectively. All animals except normal mice were sensitized and challenged with ovalbumin (OVA) to induce airway allergic inflammation. Hallmarks of AAD were examined by histological analysis and ELISA. The variation in intestinal bacterial composition was assessed by qualitative analysis of 16S ribosomal DNA (rDNA) content in fecal samples using real-time PCR.Low-fiber diet aggravated inflammatory response in ovalbumin-induced allergic mice, whereas dietary fiber intake significantly suppressed the allergic responses, attenuated allergic symptoms of nasal rubbing and sneezing, decreased the pathology of eosinophil infiltration and goblet cell metaplasia in the nasal mucosa and lung, inhibited serum OVA-specific IgE levels, and lowered the levels of Th2 cytokines in NALF and BALF, but, increased Th1 (IFN-γ) cytokines. Additionally, dietary fiber intake also increased the proportion of Bacteroidetes and Actinobacteria, and decreased Firmicutes and Proteobacteria. Levels of probiotic bacteria, such as Lactobacillus and Bifidobacterium, were upgraded significantly.Long-term deficiency of dietary fiber intake increases the susceptibility to AAD, whereas proper fiber supplementation promotes effectively the balance of Th1/Th2 immunity and then attenuates allergic inflammatory responses significantly, as well as optimizes the structure of intestinal microbiota, which suggests potential for novel preventive and therapeutic intervention." @default.
• W2261232513 created "2016-06-24" @default.
• W2261232513 creator A5007312763 @default.
• W2261232513 creator A5016795467 @default.
• W2261232513 creator A5035588077 @default.
• W2261232513 creator A5072814172 @default.
• W2261232513 creator A5077558876 @default.
• W2261232513 creator A5090949378 @default.
• W2261232513 creator A5091380719 @default.
• W2261232513 date "2016-02-12" @default.
• W2261232513 modified "2023-10-13" @default.
• W2261232513 title "Dietary Fiber Intake Regulates Intestinal Microflora and Inhibits Ovalbumin-Induced Allergic Airway Inflammation in a Mouse Model" @default.
• W2261232513 cites W1527957830 @default.
• W2261232513 cites W1540439446 @default.
• W2261232513 cites W1667559476 @default.
• W2261232513 cites W1929605979 @default.
• W2261232513 cites W1968105193 @default.
• W2261232513 cites W1969179523 @default.
• W2261232513 cites W1969595537 @default.
• W2261232513 cites W1979507095 @default.
• W2261232513 cites W1983936313 @default.
• W2261232513 cites W1988821718 @default.
• W2261232513 cites W1992153121 @default.
• W2261232513 cites W1992396801 @default.
• W2261232513 cites W2007589345 @default.
• W2261232513 cites W2008121639 @default.
• W2261232513 cites W2008993230 @default.
• W2261232513 cites W2011501210 @default.
• W2261232513 cites W2030618731 @default.
• W2261232513 cites W2032982186 @default.
• W2261232513 cites W2035831689 @default.
• W2261232513 cites W2036789000 @default.
• W2261232513 cites W2038217946 @default.
• W2261232513 cites W2040870202 @default.
• W2261232513 cites W2041267049 @default.
• W2261232513 cites W2041338917 @default.
• W2261232513 cites W2044378539 @default.
• W2261232513 cites W2048469790 @default.
• W2261232513 cites W2053620346 @default.
• W2261232513 cites W2068234766 @default.
• W2261232513 cites W2071424821 @default.
• W2261232513 cites W2075046040 @default.
• W2261232513 cites W2085175109 @default.
• W2261232513 cites W2085854795 @default.
• W2261232513 cites W2142871624 @default.
• W2261232513 cites W2146648075 @default.
• W2261232513 cites W2157151925 @default.
• W2261232513 cites W2159590190 @default.
• W2261232513 cites W2162564744 @default.
• W2261232513 cites W2162786126 @default.
• W2261232513 cites W2164132449 @default.
• W2261232513 cites W2167142729 @default.
• W2261232513 cites W2167256910 @default.
• W2261232513 cites W2169509583 @default.
• W2261232513 cites W2256296234 @default.
• W2261232513 cites W2402794263 @default.
• W2261232513 cites W2417154838 @default.
• W2261232513 cites W24728340 @default.
• W2261232513 cites W769303411 @default.
• W2261232513 doi "https://doi.org/10.1371/journal.pone.0147778" @default.
• W2261232513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4752249" @default.
• W2261232513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26872019" @default.
• W2261232513 hasPublicationYear "2016" @default.
• W2261232513 type Work @default.
• W2261232513 sameAs 2261232513 @default.
• W2261232513 citedByCount "71" @default.
• W2261232513 countsByYear W22612325132015 @default.
• W2261232513 countsByYear W22612325132017 @default.
• W2261232513 countsByYear W22612325132018 @default.
• W2261232513 countsByYear W22612325132019 @default.
• W2261232513 countsByYear W22612325132020 @default.
• W2261232513 countsByYear W22612325132021 @default.
• W2261232513 countsByYear W22612325132022 @default.
• W2261232513 countsByYear W22612325132023 @default.
• W2261232513 crossrefType "journal-article" @default.
• W2261232513 hasAuthorship W2261232513A5007312763 @default.
• W2261232513 hasAuthorship W2261232513A5016795467 @default.
• W2261232513 hasAuthorship W2261232513A5035588077 @default.
• W2261232513 hasAuthorship W2261232513A5072814172 @default.
• W2261232513 hasAuthorship W2261232513A5077558876 @default.
• W2261232513 hasAuthorship W2261232513A5090949378 @default.
• W2261232513 hasAuthorship W2261232513A5091380719 @default.
• W2261232513 hasBestOaLocation W22612325131 @default.
• W2261232513 hasConcept C104317684 @default.
• W2261232513 hasConcept C141105273 @default.
• W2261232513 hasConcept C142724271 @default.
• W2261232513 hasConcept C159654299 @default.
• W2261232513 hasConcept C203014093 @default.
• W2261232513 hasConcept C207480886 @default.
• W2261232513 hasConcept C2775941134 @default.
• W2261232513 hasConcept C2776042228 @default.
• W2261232513 hasConcept C2776914184 @default.
• W2261232513 hasConcept C2776946954 @default.
• W2261232513 hasConcept C2777037409 @default.
• W2261232513 hasConcept C2777695942 @default.
• W2261232513 hasConcept C2779675166 @default.
• W2261232513 hasConcept C42062724 @default.
• W2261232513 hasConcept C529295009 @default.

• next