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- W2261303987 abstract "The term gastrointestinal stromal tumor (GIST) has been used to refer to the largest group of mesenchymal tumors in the gastrointestinal tract. Recent studies have demonstrated the presence in most GISTs of c-kit gene mutations that cause activation of a c-kit tyrosine kinase. The c-kit proto-oncogene protein is identfied by an immunohistochemical stain positive for CD117. GISTs have now been reclassfled so that cell-surface expression of CD117 is required for diagnosis. STI 571, an inhibitor of the kinase domain of c-kit is a newly developed therapy for GIST. We reviewed 95 cases of GI tract stromal tumors diagnosed by pathology between October 1992 and November 2002 in a single medical center. We performed immunohistochemical staining for CD117, CD34, SMA and S-100 on those specimens. The patients were grouped according to the results of the CD117 immunostaining, and the groups were compared for characteristics and survival. We also analyzed factors associated with prognosis in the CD117 positive group. Of the 95 cases, CD117 immunostaining was positive in 81 cases (85.2%) and negative in 14 (14.8%). Factors associated with a positive CD117 immunostain were male sex, gastric tumors, and a positive CD34. There was no sign (ficant difference in the survival of patients with and without CD117 (68.9 months vs. 59.3 months, F＞0.05). Significant risk factors for a poor prognosis in the group positive for CD117 included tumor size＞5cm, limited resectability, metastasis, or recurrence. In conclusion, immunostaining for CD117 has provided a new definition of GIST, separating these tumors from others of mesenchymal origin. However, in our experience, survival was not influenced by whether the tumor was positive or negative for CD117. Tumor size and tumor metastasis are the most important prognostic factors of survival in our series." @default.
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- W2261303987 date "2004-06-01" @default.
- W2261303987 modified "2023-09-23" @default.
- W2261303987 title "The Clinical Significance of CD117(c-kit) in Gastrointestinal Stromal Tumors" @default.
- W2261303987 doi "https://doi.org/10.6557/gjt.200406_21(2).0001" @default.
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