FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2261323878> ?p ?o ?g. }

• W2261323878 endingPage "2121" @default.
• W2261323878 startingPage "2116" @default.
• W2261323878 abstract "During skeletal muscle development, myoblasts fuse to form multinucleated myofibers. Myomaker [Transmembrane protein 8c (TMEM8c)] is a muscle-specific protein that is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells; however, the structure and biochemical properties of this membrane protein have not been explored. Here, we used CRISPR/Cas9 mutagenesis to disrupt myomaker expression in the C2C12 muscle cell line, which resulted in complete blockade to fusion. To define the functional domains of myomaker required to direct fusion, we established a heterologous cell-cell fusion system, in which fibroblasts expressing mutant versions of myomaker were mixed with WT myoblasts. Our data indicate that the majority of myomaker is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. We show that myomaker function is conserved in other mammalian orthologs; however, related family members (TMEM8a and TMEM8b) do not exhibit fusogenic activity. These findings represent an important step toward deciphering the cellular components and mechanisms that control myoblast fusion and muscle formation." @default.
• W2261323878 created "2016-06-24" @default.
• W2261323878 creator A5014669976 @default.
• W2261323878 creator A5023265234 @default.
• W2261323878 creator A5024308650 @default.
• W2261323878 creator A5030368185 @default.
• W2261323878 creator A5078423392 @default.
• W2261323878 creator A5084182062 @default.
• W2261323878 creator A5086724975 @default.
• W2261323878 date "2016-02-08" @default.
• W2261323878 modified "2023-10-16" @default.
• W2261323878 title "Structure–function analysis of myomaker domains required for myoblast fusion" @default.
• W2261323878 cites W1849347232 @default.
• W2261323878 cites W1975304761 @default.
• W2261323878 cites W1980811848 @default.
• W2261323878 cites W1981489492 @default.
• W2261323878 cites W1986130046 @default.
• W2261323878 cites W1988594478 @default.
• W2261323878 cites W1995486491 @default.
• W2261323878 cites W1998279163 @default.
• W2261323878 cites W2003171404 @default.
• W2261323878 cites W2003499832 @default.
• W2261323878 cites W2004751759 @default.
• W2261323878 cites W2006224414 @default.
• W2261323878 cites W2009100350 @default.
• W2261323878 cites W2011014862 @default.
• W2261323878 cites W2013704433 @default.
• W2261323878 cites W2013898345 @default.
• W2261323878 cites W2014593313 @default.
• W2261323878 cites W2015814220 @default.
• W2261323878 cites W2062336149 @default.
• W2261323878 cites W2064815984 @default.
• W2261323878 cites W2104980202 @default.
• W2261323878 cites W2107283445 @default.
• W2261323878 cites W2121469024 @default.
• W2261323878 cites W2136479767 @default.
• W2261323878 cites W2138313400 @default.
• W2261323878 cites W2170191823 @default.
• W2261323878 cites W2210789530 @default.
• W2261323878 doi "https://doi.org/10.1073/pnas.1600101113" @default.
• W2261323878 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4776501" @default.
• W2261323878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26858401" @default.
• W2261323878 hasPublicationYear "2016" @default.
• W2261323878 type Work @default.
• W2261323878 sameAs 2261323878 @default.
• W2261323878 citedByCount "64" @default.
• W2261323878 countsByYear W22613238782016 @default.
• W2261323878 countsByYear W22613238782017 @default.
• W2261323878 countsByYear W22613238782018 @default.
• W2261323878 countsByYear W22613238782019 @default.
• W2261323878 countsByYear W22613238782020 @default.
• W2261323878 countsByYear W22613238782021 @default.
• W2261323878 countsByYear W22613238782022 @default.
• W2261323878 countsByYear W22613238782023 @default.
• W2261323878 crossrefType "journal-article" @default.
• W2261323878 hasAuthorship W2261323878A5014669976 @default.
• W2261323878 hasAuthorship W2261323878A5023265234 @default.
• W2261323878 hasAuthorship W2261323878A5024308650 @default.
• W2261323878 hasAuthorship W2261323878A5030368185 @default.
• W2261323878 hasAuthorship W2261323878A5078423392 @default.
• W2261323878 hasAuthorship W2261323878A5084182062 @default.
• W2261323878 hasAuthorship W2261323878A5086724975 @default.
• W2261323878 hasBestOaLocation W22613238781 @default.
• W2261323878 hasConcept C103038307 @default.
• W2261323878 hasConcept C104317684 @default.
• W2261323878 hasConcept C105702510 @default.
• W2261323878 hasConcept C123894998 @default.
• W2261323878 hasConcept C136403682 @default.
• W2261323878 hasConcept C143065580 @default.
• W2261323878 hasConcept C1491633281 @default.
• W2261323878 hasConcept C170493617 @default.
• W2261323878 hasConcept C207200792 @default.
• W2261323878 hasConcept C24530287 @default.
• W2261323878 hasConcept C2779959927 @default.
• W2261323878 hasConcept C2780115692 @default.
• W2261323878 hasConcept C3763915 @default.
• W2261323878 hasConcept C40767141 @default.
• W2261323878 hasConcept C41625074 @default.
• W2261323878 hasConcept C55493867 @default.
• W2261323878 hasConcept C60278653 @default.
• W2261323878 hasConcept C86803240 @default.
• W2261323878 hasConcept C92488253 @default.
• W2261323878 hasConcept C95444343 @default.
• W2261323878 hasConceptScore W2261323878C103038307 @default.
• W2261323878 hasConceptScore W2261323878C104317684 @default.
• W2261323878 hasConceptScore W2261323878C105702510 @default.
• W2261323878 hasConceptScore W2261323878C123894998 @default.
• W2261323878 hasConceptScore W2261323878C136403682 @default.
• W2261323878 hasConceptScore W2261323878C143065580 @default.
• W2261323878 hasConceptScore W2261323878C1491633281 @default.
• W2261323878 hasConceptScore W2261323878C170493617 @default.
• W2261323878 hasConceptScore W2261323878C207200792 @default.
• W2261323878 hasConceptScore W2261323878C24530287 @default.
• W2261323878 hasConceptScore W2261323878C2779959927 @default.
• W2261323878 hasConceptScore W2261323878C2780115692 @default.
• W2261323878 hasConceptScore W2261323878C3763915 @default.
• W2261323878 hasConceptScore W2261323878C40767141 @default.
• W2261323878 hasConceptScore W2261323878C41625074 @default.

• next