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- W2261393485 abstract "Some substituted imidazole compounds were synthesized and their analgesic activities were determined on the Swiss albino mice (25-35 g) of either sex. During the synthesis, 2-substituted-4,5-diphenyl imidazole compounds were obtained by the reaction of benzil with some substituted or nonsubstituted aldehyde derivatives, in the presence of ammonium acetate. 1-Ethyl-2-substituted-4,5-diphenyl imidazole compounds were obtained by the reaction of purified 2-substituted-4,5-diphenyl imidazole derivatives with alkyl halides in THF at the presence of NaH. All spectral and elemental analyses of the compounds were completed and their structures elucidated. Analgesic activities of the compounds were examined using the Tail-Clip method. 15a (2-p-chlorophenyl-4,5-diphenyl imidazole) and 6b (1-ethyl-2-p-hydroxyphenyl-4,5-diphenyl imidazole) derivatives were found to be more active than the others and their LD50 values were found to be greater than 100 mg/kg (i.p.)." @default.
- W2261393485 created "2016-06-24" @default.
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- W2261393485 date "1999-01-01" @default.
- W2261393485 modified "2023-09-27" @default.
- W2261393485 title "Syntheses and analgesic activities of some 2-substituted-4,5-diphenyl and 1,2-disubstituted-4,5-diphenyl imidazole derivatives." @default.
- W2261393485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10326312" @default.
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