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- W2261506052 abstract "We have a particular interest in the development of LIF diagnosis in colonic tissues for clinicalapplication during endoscopy, particularly in the immediate, noninvasive diagnosis of small ormicroscopic dysplastic lesions not readily diagnosed by routine examination. In order to address themorphological and cytological origins of colonic tissue autofluorescence and quantitatively asses thecontributions of spectral signatures arising from different morphological tissue components, we haveinitiated studies of high-resolution ultraviolet laser scanning confocal fluorescence microscopy ofunstained, excised samples of normal, premalignant, and malignant colonic tissues. Confocal microscopyis particularly well suited to this investigation because of its capability to provide quantitativemeasurements of remitted tissue fluorescence intensities localized with sub-micron resolution in threedimensions. Further, optical sectioning of thin tissue sections within relatively thick tissue specimens ispossible, thus anomalous fluorescence signals arising from tissue sectioning artifacts are eliminated." @default.
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- W2261506052 date "1996-03-18" @default.
- W2261506052 modified "2023-09-23" @default.
- W2261506052 title "Quantitative Laser Scanning Confocal Autofluorescence Microscopy of Normal, Premalignant, and Malignant Colonic Tissues" @default.
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