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- W2261626136 abstract "Abstract Amyotrophic Lateral Sclerosis (ALS) is characterized by the degeneration of upper and lower motor neurons. Clinical heterogeneity is a well‐recognized feature of the disease as age of onset, site of onset and the duration of the disease can vary greatly among patients. A number of genes have been identified and associated to familial and sporadic forms of ALS but the majority of cases remains still unexplained. Recent breakthrough discoveries have demonstrated that clinical manifestations associated with ALS‐related genes are not circumscribed to motor neurons involvement. In this view, ALS appears to be linked to different conditions over a continuum or spectrum in which overlapping phenotypes may be identified. In this review, we aim to examine the increasing number of spectra , including ALS/Frontotemporal Dementia and ALS/Myopathies spectra . Considering all these neurodegenerative disorders as different phenotypes of the same spectrum can help to identify common pathological pathways and consequently new therapeutic targets in these incurable diseases." @default.
- W2261626136 created "2016-06-24" @default.
- W2261626136 creator A5009528571 @default.
- W2261626136 creator A5022091308 @default.
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- W2261626136 creator A5023451940 @default.
- W2261626136 creator A5050917934 @default.
- W2261626136 creator A5066411369 @default.
- W2261626136 date "2016-03-01" @default.
- W2261626136 modified "2023-10-16" @default.
- W2261626136 title "New ALS-Related Genes Expand the<i>Spectrum Paradigm</i>of Amyotrophic Lateral Sclerosis" @default.
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