FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2261708844> ?p ?o ?g. }

• W2261708844 endingPage "340" @default.
• W2261708844 startingPage "330" @default.
• W2261708844 abstract "Fused in sarcoma ( FUS ) is an RNA ‐binding protein that is causally associated with oncogenesis and neurodegeneration. Recently, the role of FUS in neurodegeneration has been extensively studied, because mutations in FUS are associated with amyotrophic lateral sclerosis ( ALS ), and the FUS protein has been identified as a major component of intracellular inclusions in neurodegenerative disorders including ALS and frontotemporal lobar degeneration. FUS is a key molecule in transcriptional regulation and RNA processing including processes such as pre‐messenger RNA ( mRNA ) splicing and polyadenylation. Interaction of FUS with various components of the transcription machinery, spliceosome, and the 3′‐end processing machinery has been identified. Furthermore, recent advances in high‐throughput transcriptomic profiling approaches have enabled us to determine the mechanisms of FUS ‐dependent RNA processing networks at a cellular level. These analyses have revealed that depletion of FUS in neuronal cells affects alternative splicing and alternative polyadenylation of thousands of mRNAs . Gene ontology analysis has suggested that FUS ‐modulated genes are implicated in neuronal functions and development. CLIP ‐seq of FUS has shown that FUS is frequently clustered around these alternative sites of nascent RNA . ChIP ‐seq of RNA polymerase II ( RNAP II ) has demonstrated that an interaction between FUS and nascent RNA downregulates local transcriptional activity of RNAP II , which is critically involved in RNA processing. Both alternative splicing and alternative polyadenylation are fundamental processes by which cells expand their transcriptomic diversity, and are particularly essential in the nervous system. Dependence of transcriptomic diversity on FUS makes the nervous system vulnerable to neurodegeneration, when FUS is functionally compromised. WIREs RNA 2016, 7:330–340. doi: 10.1002/wrna.1338 This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications RNA Processing > Splicing Regulation/Alternative Splicing RNA Processing > 3' End Processing" @default.
• W2261708844 created "2016-06-24" @default.
• W2261708844 creator A5017751776 @default.
• W2261708844 creator A5038516654 @default.
• W2261708844 creator A5054824968 @default.
• W2261708844 date "2016-01-28" @default.
• W2261708844 modified "2023-10-07" @default.
• W2261708844 title "<scp>FUS</scp>‐mediated regulation of alternative <scp>RNA</scp> processing in neurons: insights from global transcriptome analysis" @default.
• W2261708844 cites W1740080203 @default.
• W2261708844 cites W1941145541 @default.
• W2261708844 cites W1963826942 @default.
• W2261708844 cites W1967637890 @default.
• W2261708844 cites W1969196565 @default.
• W2261708844 cites W1978547782 @default.
• W2261708844 cites W1979580608 @default.
• W2261708844 cites W1993084790 @default.
• W2261708844 cites W1993556679 @default.
• W2261708844 cites W2003395646 @default.
• W2261708844 cites W2004318896 @default.
• W2261708844 cites W2007239552 @default.
• W2261708844 cites W2011920499 @default.
• W2261708844 cites W2021678907 @default.
• W2261708844 cites W2029979788 @default.
• W2261708844 cites W2031567993 @default.
• W2261708844 cites W2034742666 @default.
• W2261708844 cites W2035426129 @default.
• W2261708844 cites W2038438413 @default.
• W2261708844 cites W2040410152 @default.
• W2261708844 cites W2051470096 @default.
• W2261708844 cites W2052897134 @default.
• W2261708844 cites W2053863700 @default.
• W2261708844 cites W2054077521 @default.
• W2261708844 cites W2055720906 @default.
• W2261708844 cites W2056181171 @default.
• W2261708844 cites W2056608604 @default.
• W2261708844 cites W2061747833 @default.
• W2261708844 cites W2065387333 @default.
• W2261708844 cites W2068190648 @default.
• W2261708844 cites W2068994511 @default.
• W2261708844 cites W2072898686 @default.
• W2261708844 cites W2073068786 @default.
• W2261708844 cites W2074726646 @default.
• W2261708844 cites W2075186362 @default.
• W2261708844 cites W2076363659 @default.
• W2261708844 cites W2085399699 @default.
• W2261708844 cites W2085717785 @default.
• W2261708844 cites W2088017477 @default.
• W2261708844 cites W2089423734 @default.
• W2261708844 cites W2093140735 @default.
• W2261708844 cites W2093827499 @default.
• W2261708844 cites W2096352618 @default.
• W2261708844 cites W2097630727 @default.
• W2261708844 cites W2098980484 @default.
• W2261708844 cites W2103214559 @default.
• W2261708844 cites W2103964281 @default.
• W2261708844 cites W2105776281 @default.
• W2261708844 cites W2107798773 @default.
• W2261708844 cites W2109835272 @default.
• W2261708844 cites W2110871180 @default.
• W2261708844 cites W2112538318 @default.
• W2261708844 cites W2115670698 @default.
• W2261708844 cites W2117506397 @default.
• W2261708844 cites W2118834857 @default.
• W2261708844 cites W2118922947 @default.
• W2261708844 cites W2119176236 @default.
• W2261708844 cites W2129214044 @default.
• W2261708844 cites W2135607950 @default.
• W2261708844 cites W2137807688 @default.
• W2261708844 cites W2142798429 @default.
• W2261708844 cites W2147095990 @default.
• W2261708844 cites W2151638204 @default.
• W2261708844 cites W2152675476 @default.
• W2261708844 cites W2154431984 @default.
• W2261708844 cites W2155804510 @default.
• W2261708844 cites W2157580663 @default.
• W2261708844 cites W2161029017 @default.
• W2261708844 cites W2166494447 @default.
• W2261708844 cites W2169685494 @default.
• W2261708844 cites W2266499054 @default.
• W2261708844 cites W61004016 @default.
• W2261708844 cites W832413641 @default.
• W2261708844 doi "https://doi.org/10.1002/wrna.1338" @default.
• W2261708844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26822113" @default.
• W2261708844 hasPublicationYear "2016" @default.
• W2261708844 type Work @default.
• W2261708844 sameAs 2261708844 @default.
• W2261708844 citedByCount "30" @default.
• W2261708844 countsByYear W22617088442016 @default.
• W2261708844 countsByYear W22617088442017 @default.
• W2261708844 countsByYear W22617088442018 @default.
• W2261708844 countsByYear W22617088442019 @default.
• W2261708844 countsByYear W22617088442020 @default.
• W2261708844 countsByYear W22617088442021 @default.
• W2261708844 countsByYear W22617088442022 @default.
• W2261708844 countsByYear W22617088442023 @default.
• W2261708844 crossrefType "journal-article" @default.
• W2261708844 hasAuthorship W2261708844A5017751776 @default.
• W2261708844 hasAuthorship W2261708844A5038516654 @default.

• next