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- W2261732011 abstract "Disturbances of axonal excitability determine many symptoms in patients. There are now rapid and reliable physiologic tests, using tracking, that can be used in vivo to study axonal excitability. In humans, sensory and motor axons differ in two conductances, with consequent implications for the susceptibility to conduction block [motor axons] and to ectopic activity [sensory axons]: The Na v 1.6 Na + channel at the healthy mature node of Ranvier can have two gating modes: transient (∼98–99% total Na + conductance) and persistent (∼1–2% total Na + conductance). The persistent current is greater in sensory axons than motor. The persistent current is the reason for the difference in strength-duration properties, ∣ SD and rheobase. Most of this is because sensory axons are ∼4 mV more depolarized . The hyperpolarisation-activated current (I h ) is internodally located , passes a depolarizing current, dependent on HCN channels. I h contributes to resting membrane potential, and is more active on sensory axons than motor [and more on motor axons of low threshold ]. The role of I h is to limit the neuronal/axonal hyperpolarisation, during, e.g., activity . The excitability of peripheral nerve axons can be altered in central diseases, and this will be illustrated for K + channel mutations underlying EA1 and BFNE." @default.
- W2261732011 created "2016-06-24" @default.
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- W2261732011 date "2016-03-01" @default.
- W2261732011 modified "2023-09-27" @default.
- W2261732011 title "Recent insights into axonal physiology and its measurement" @default.
- W2261732011 doi "https://doi.org/10.1016/j.clinph.2015.11.078" @default.
- W2261732011 hasPublicationYear "2016" @default.
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