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- W2261849095 abstract "BACKGROUND AND PURPOSE: Understanding risk factors for intracranial aneurysm growth is important for patient management. We performed a meta-analysis examining risk factors for intracranial aneurysm growth in longitudinal studies and examined the association between aneurysm growth and rupture. MATERIALS AND METHODS: We searched the literature for longitudinal studies of patients with unruptured aneurysms. We examined the associations of demographics, multiple aneurysms, prior subarachnoid hemorrhage, family history of aneurysm or subarachnoid hemorrhage, smoking, and hypertension; and aneurysm shape, size, and location with aneurysm growth. We studied the association between aneurysm growth and rupture. A meta-analysis was performed by using a random-effects model by using summary statistics from included studies. RESULTS: Twenty-one studies including 3954 patients with 4990 aneurysms with 13,294 aneurysm-years of follow-up were included. The overall proportion of growing aneurysms was 3.0% per aneurysm-year (95% CI, 2.0%–4.0%). Patient risk factors for growth included age older than 50 years (3.8% per year versus 0.9% per year, P CONCLUSIONS: Observational evidence provided multiple clinical and anatomic risk factors for aneurysm growth, including age older than 50 years, female sex, smoking history, and nonsaccular shape. These findings should be considered when counseling patients regarding the natural history of unruptured intracranial aneurysms." @default.
- W2261849095 created "2016-06-24" @default.
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- W2261849095 date "2015-11-26" @default.
- W2261849095 modified "2023-10-10" @default.
- W2261849095 title "Risk Factors for Growth of Intracranial Aneurysms: A Systematic Review and Meta-Analysis" @default.
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- W2261849095 doi "https://doi.org/10.3174/ajnr.a4575" @default.
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