Matches in SemOpenAlex for { <https://semopenalex.org/work/W2261880149> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2261880149 endingPage "28" @default.
- W2261880149 startingPage "618" @default.
- W2261880149 abstract "The antinociceptive effects of the S(+)-enantiomer of flurbiprofen (potent inhibitor of cyclooxygenase) and the R(-)-enantiomer (500 times less potent) were investigated in the spinal cord of 20 anesthetized rats. In lumbar segments, 20 wide-dynamic-range dorsal horn neurons with knee joint input were recorded extracellularly. After induction of an acute inflammation in the knee joint by kaolin and carrageenan, the neurons developed hyperexcitability consisting of enhanced responses to stimuli applied to the inflamed knee and the noninflamed ankle and an expansion of receptive fields. Intravenous administration of R(-)-flurbiprofen (1-9 mg/kg) and S(+)-flurbiprofen (0.3-9 mg/kg) at 5.5 to 8.5 h after kaolin, dose dependently reduced the neurons' responses to pressure applied to the inflamed knee (18 of 18 neurons) and the noninflamed ankle (17 of 17 neurons) and paw (8 of 8 neurons). R(-)-flurbiprofen decreased the receptive field size in 8 of 16 neurons, S(+)-flurbiprofen in 10 of 16 neurons. The suppressive effects started 3 to 6 min and reached a maximum 9 to 15 min after i.v. administration. S(+)-flurbiprofen was more potent than the R(-)-enantiomer. When injected directly into the knee joint, S(+)-flurbiprofen (50 and 80 micrograms), but not the R(-)-enantiomer (100 and 180 micrograms) reduced the hyperexcitability in 12 of 12 neurons. These results suggest a central site of antinociceptive action for R(-)-flurbiprofen and S(+)-flurbiprofen and an additional peripheral site for S(+)-flurbiprofen. The doses used in these experiments did not produce any sedative effects in rats subjected to behavioral testing." @default.
- W2261880149 created "2016-06-24" @default.
- W2261880149 creator A5007229472 @default.
- W2261880149 creator A5007527972 @default.
- W2261880149 creator A5026031162 @default.
- W2261880149 creator A5027292872 @default.
- W2261880149 creator A5054742181 @default.
- W2261880149 creator A5075165478 @default.
- W2261880149 creator A5078612562 @default.
- W2261880149 date "1995-11-01" @default.
- W2261880149 modified "2023-09-27" @default.
- W2261880149 title "Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation." @default.
- W2261880149 cites W1824081845 @default.
- W2261880149 cites W1975051009 @default.
- W2261880149 cites W1978926613 @default.
- W2261880149 cites W1983587864 @default.
- W2261880149 cites W1985024448 @default.
- W2261880149 cites W1990046688 @default.
- W2261880149 cites W2003321326 @default.
- W2261880149 cites W2008574207 @default.
- W2261880149 cites W2014005116 @default.
- W2261880149 cites W2015072125 @default.
- W2261880149 cites W2018467822 @default.
- W2261880149 cites W2020841267 @default.
- W2261880149 cites W2022869811 @default.
- W2261880149 cites W2023265834 @default.
- W2261880149 cites W2030542374 @default.
- W2261880149 cites W2037043363 @default.
- W2261880149 cites W2040393757 @default.
- W2261880149 cites W2052840755 @default.
- W2261880149 cites W2054416100 @default.
- W2261880149 cites W2075429563 @default.
- W2261880149 cites W2078360083 @default.
- W2261880149 cites W2078941129 @default.
- W2261880149 cites W2089221066 @default.
- W2261880149 cites W2129447376 @default.
- W2261880149 cites W2218044579 @default.
- W2261880149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7473147" @default.
- W2261880149 hasPublicationYear "1995" @default.
- W2261880149 type Work @default.
- W2261880149 sameAs 2261880149 @default.
- W2261880149 citedByCount "12" @default.
- W2261880149 countsByYear W22618801492016 @default.
- W2261880149 crossrefType "journal-article" @default.
- W2261880149 hasAuthorship W2261880149A5007229472 @default.
- W2261880149 hasAuthorship W2261880149A5007527972 @default.
- W2261880149 hasAuthorship W2261880149A5026031162 @default.
- W2261880149 hasAuthorship W2261880149A5027292872 @default.
- W2261880149 hasAuthorship W2261880149A5054742181 @default.
- W2261880149 hasAuthorship W2261880149A5075165478 @default.
- W2261880149 hasAuthorship W2261880149A5078612562 @default.
- W2261880149 hasConcept C118552586 @default.
- W2261880149 hasConcept C126322002 @default.
- W2261880149 hasConcept C15490471 @default.
- W2261880149 hasConcept C170493617 @default.
- W2261880149 hasConcept C181199279 @default.
- W2261880149 hasConcept C185592680 @default.
- W2261880149 hasConcept C2779689624 @default.
- W2261880149 hasConcept C2780775167 @default.
- W2261880149 hasConcept C2780820201 @default.
- W2261880149 hasConcept C2781000538 @default.
- W2261880149 hasConcept C42219234 @default.
- W2261880149 hasConcept C55493867 @default.
- W2261880149 hasConcept C71924100 @default.
- W2261880149 hasConcept C98274493 @default.
- W2261880149 hasConceptScore W2261880149C118552586 @default.
- W2261880149 hasConceptScore W2261880149C126322002 @default.
- W2261880149 hasConceptScore W2261880149C15490471 @default.
- W2261880149 hasConceptScore W2261880149C170493617 @default.
- W2261880149 hasConceptScore W2261880149C181199279 @default.
- W2261880149 hasConceptScore W2261880149C185592680 @default.
- W2261880149 hasConceptScore W2261880149C2779689624 @default.
- W2261880149 hasConceptScore W2261880149C2780775167 @default.
- W2261880149 hasConceptScore W2261880149C2780820201 @default.
- W2261880149 hasConceptScore W2261880149C2781000538 @default.
- W2261880149 hasConceptScore W2261880149C42219234 @default.
- W2261880149 hasConceptScore W2261880149C55493867 @default.
- W2261880149 hasConceptScore W2261880149C71924100 @default.
- W2261880149 hasConceptScore W2261880149C98274493 @default.
- W2261880149 hasIssue "2" @default.
- W2261880149 hasLocation W22618801491 @default.
- W2261880149 hasOpenAccess W2261880149 @default.
- W2261880149 hasPrimaryLocation W22618801491 @default.
- W2261880149 hasRelatedWork W1525139228 @default.
- W2261880149 hasRelatedWork W1976460300 @default.
- W2261880149 hasRelatedWork W1990756964 @default.
- W2261880149 hasRelatedWork W1992819691 @default.
- W2261880149 hasRelatedWork W2003321326 @default.
- W2261880149 hasRelatedWork W2014005116 @default.
- W2261880149 hasRelatedWork W2032043921 @default.
- W2261880149 hasRelatedWork W2110132542 @default.
- W2261880149 hasRelatedWork W2344631517 @default.
- W2261880149 hasRelatedWork W4291014994 @default.
- W2261880149 hasVolume "275" @default.
- W2261880149 isParatext "false" @default.
- W2261880149 isRetracted "false" @default.
- W2261880149 magId "2261880149" @default.
- W2261880149 workType "article" @default.