Matches in SemOpenAlex for { <https://semopenalex.org/work/W2261885330> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2261885330 endingPage "1384" @default.
- W2261885330 startingPage "1378" @default.
- W2261885330 abstract "Previous studies have documented that treatment with angiotensin-converting enzyme (ACE) inhibitors prevents spontaneous proteinuria and enhances the glomerular ultrafiltration coefficient in male MWF/Ztm rats. The aim of this study was to study whether these beneficial effects of ACE inhibitors on glomerular capillary wall function are derived from the preservation of its ultrastructure. Conventional morphometrical analysis of kidney tissue, by light and electron microscopy, was used to quantify glomerular structural changes in the male MWF/Ztm rats treated with the ACE inhibitor cilazapril for 2 and 6 months and in age-matched untreated controls. At the end of the observation periods, both systolic blood pressure and urinary protein excretion were significantly reduced in treated animals as compared with controls. Glomerular volume increased significantly with time but was comparable in control and in treated rats. Surface area available for filtration (measured as peripheral capillary wall) was comparable in control and in treated animals at the same time and increased significantly with time only in treated rats. Mesangial volume was significantly higher in cilazapril-treated animals than in controls after 2 months of treatment and was comparable after 6 months. ACE inhibitor treatment did not induce significant ultrastructural changes such as basement membrane thickness, configuration of epithelial podocytes, and the width and the frequency of the epithelial slit diaphragms. These results indicate that the previously observed increase in the glomerular ultrafiltration coefficient by an ACE inhibitor in these animals is not the consequence of changes in filtering surface area but likely reflects an increase in membrane hydraulic permeability.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2261885330 created "2016-06-24" @default.
- W2261885330 creator A5006476467 @default.
- W2261885330 creator A5027726576 @default.
- W2261885330 creator A5029616044 @default.
- W2261885330 creator A5038307319 @default.
- W2261885330 creator A5050920108 @default.
- W2261885330 creator A5076316519 @default.
- W2261885330 date "1994-12-01" @default.
- W2261885330 modified "2023-10-17" @default.
- W2261885330 title "Effects of angiotensin-converting enzyme inhibition on glomerular capillary wall ultrastructure in MWF/Ztm rats." @default.
- W2261885330 doi "https://doi.org/10.1681/asn.v561378" @default.
- W2261885330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7894005" @default.
- W2261885330 hasPublicationYear "1994" @default.
- W2261885330 type Work @default.
- W2261885330 sameAs 2261885330 @default.
- W2261885330 citedByCount "24" @default.
- W2261885330 countsByYear W22618853302015 @default.
- W2261885330 countsByYear W22618853302016 @default.
- W2261885330 countsByYear W22618853302019 @default.
- W2261885330 countsByYear W22618853302020 @default.
- W2261885330 crossrefType "journal-article" @default.
- W2261885330 hasAuthorship W2261885330A5006476467 @default.
- W2261885330 hasAuthorship W2261885330A5027726576 @default.
- W2261885330 hasAuthorship W2261885330A5029616044 @default.
- W2261885330 hasAuthorship W2261885330A5038307319 @default.
- W2261885330 hasAuthorship W2261885330A5050920108 @default.
- W2261885330 hasAuthorship W2261885330A5076316519 @default.
- W2261885330 hasBestOaLocation W22618853301 @default.
- W2261885330 hasConcept C126322002 @default.
- W2261885330 hasConcept C134018914 @default.
- W2261885330 hasConcept C159641895 @default.
- W2261885330 hasConcept C185592680 @default.
- W2261885330 hasConcept C27016395 @default.
- W2261885330 hasConcept C2776115139 @default.
- W2261885330 hasConcept C2779561371 @default.
- W2261885330 hasConcept C2779611605 @default.
- W2261885330 hasConcept C2780091579 @default.
- W2261885330 hasConcept C50817676 @default.
- W2261885330 hasConcept C55493867 @default.
- W2261885330 hasConcept C71924100 @default.
- W2261885330 hasConcept C84393581 @default.
- W2261885330 hasConceptScore W2261885330C126322002 @default.
- W2261885330 hasConceptScore W2261885330C134018914 @default.
- W2261885330 hasConceptScore W2261885330C159641895 @default.
- W2261885330 hasConceptScore W2261885330C185592680 @default.
- W2261885330 hasConceptScore W2261885330C27016395 @default.
- W2261885330 hasConceptScore W2261885330C2776115139 @default.
- W2261885330 hasConceptScore W2261885330C2779561371 @default.
- W2261885330 hasConceptScore W2261885330C2779611605 @default.
- W2261885330 hasConceptScore W2261885330C2780091579 @default.
- W2261885330 hasConceptScore W2261885330C50817676 @default.
- W2261885330 hasConceptScore W2261885330C55493867 @default.
- W2261885330 hasConceptScore W2261885330C71924100 @default.
- W2261885330 hasConceptScore W2261885330C84393581 @default.
- W2261885330 hasIssue "6" @default.
- W2261885330 hasLocation W22618853301 @default.
- W2261885330 hasOpenAccess W2261885330 @default.
- W2261885330 hasPrimaryLocation W22618853301 @default.
- W2261885330 hasRelatedWork W1997518038 @default.
- W2261885330 hasRelatedWork W1998672586 @default.
- W2261885330 hasRelatedWork W2013706992 @default.
- W2261885330 hasRelatedWork W2015679682 @default.
- W2261885330 hasRelatedWork W2068435782 @default.
- W2261885330 hasRelatedWork W2160709476 @default.
- W2261885330 hasRelatedWork W2186768350 @default.
- W2261885330 hasRelatedWork W2398445761 @default.
- W2261885330 hasRelatedWork W2415614104 @default.
- W2261885330 hasRelatedWork W2790461664 @default.
- W2261885330 hasVolume "5" @default.
- W2261885330 isParatext "false" @default.
- W2261885330 isRetracted "false" @default.
- W2261885330 magId "2261885330" @default.
- W2261885330 workType "article" @default.