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- W2262115292 abstract "Objective To find the association between expression of the KAI1 gene and metastasis of laryngeal carcinoma by determining expression of the KAI1 protein in human laryngeal squamous cell carcinomas and metastatic lymph nodes.Methods Using the immunohistochemical S-P technique,we studied the expression of KAI1 in 40 laryngeal squamous cell carcinoma specimens,13 metastatic lymph node specimens and 30 carcinoma normal side tissue specimens with the monoclonal antibody of KAI1.Correlations of expression of the KAI1 gene to clinicopathological factors were statistically analyzed.Results The KAI1-positive rates in carcinoma normal side tissues,laryngeal squamous cell carcinoma and metastatic lymph nodes were 93.33%(28/30),62.5%(25/40)and 30.77%(4/13)respectively,and the differences were statistically significant(P0.05).Expression of the KAI1 gene was related to the clinical stage(P0.05).There was no relationship of expression of the KAI1 gene to the patients' gender,the patients' age,the primary site of tumor,pathological grades and lymphatic metastasis(P0.05).Conclusion There is a significant reduction in expression of the KAI1 gene in metastatic lymph nodes compared with laryngeal squamous cell carcinomas.The KAI1 gene may play a role in the metastasis of laryngeal carcinomas." @default.
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- W2262115292 date "2010-01-01" @default.
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- W2262115292 title "Expression of the KAI1 gene in laryngeal carcinoma and metastatic lymph nodes." @default.
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