Matches in SemOpenAlex for { <https://semopenalex.org/work/W2262228347> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2262228347 abstract "Transcription is known to be regulated by chromatin-associated proteins containing protein domains that specifically recognize distinct covalent post-translational histone modifications. However, it has been unclear whether similar mechanisms are involved in mammalian DNA recombination. Here, we show that RAG2 – an essential component of the eukaryotic RAG1/2 V(D)J recombinase, that mediates antigen receptor gene assembly in developing lymphocytes – contains a plant homeodomain (PHD) finger that specifically recognizes histone H3 trimethylated at lysine 4 (H3K4me3). A high-resolution crystal structure of the RAG2PHD-H3K4me3 complex reveals the molecular basis of H3K4me3-recognition by RAG2. Mutations that abrogate RAG2's recognition of H3K4me3 severely impair V(D)J recombination in vivo. Reducing the level of H3K4me3 similarly leads to a decrease in V(D)J recombination in vivo. Notably, a conserved tryptophan residue (W453) that constitutes a key structural component of the K4me3-binding surface and is essential for RAG2's recognition of H3K4me3 is mutated in patients with immunodeficiency syndromes. Together our results identify a novel function for histone methylation in mammalian DNA recombination. In addition, we provide the first evidence suggesting that disrupting the read-out of histone modifications can cause an inherited human disease." @default.
- W2262228347 created "2016-06-24" @default.
- W2262228347 creator A5006011806 @default.
- W2262228347 creator A5017311778 @default.
- W2262228347 creator A5018161230 @default.
- W2262228347 creator A5029274270 @default.
- W2262228347 creator A5031737281 @default.
- W2262228347 creator A5036925851 @default.
- W2262228347 creator A5060549316 @default.
- W2262228347 creator A5069105266 @default.
- W2262228347 creator A5075159160 @default.
- W2262228347 date "2008-03-01" @default.
- W2262228347 modified "2023-10-16" @default.
- W2262228347 title "RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination" @default.
- W2262228347 doi "https://doi.org/10.1096/fasebj.22.1_supplement.600.2" @default.
- W2262228347 hasPublicationYear "2008" @default.
- W2262228347 type Work @default.
- W2262228347 sameAs 2262228347 @default.
- W2262228347 citedByCount "2" @default.
- W2262228347 countsByYear W22622283472022 @default.
- W2262228347 crossrefType "journal-article" @default.
- W2262228347 hasAuthorship W2262228347A5006011806 @default.
- W2262228347 hasAuthorship W2262228347A5017311778 @default.
- W2262228347 hasAuthorship W2262228347A5018161230 @default.
- W2262228347 hasAuthorship W2262228347A5029274270 @default.
- W2262228347 hasAuthorship W2262228347A5031737281 @default.
- W2262228347 hasAuthorship W2262228347A5036925851 @default.
- W2262228347 hasAuthorship W2262228347A5060549316 @default.
- W2262228347 hasAuthorship W2262228347A5069105266 @default.
- W2262228347 hasAuthorship W2262228347A5075159160 @default.
- W2262228347 hasConcept C10058791 @default.
- W2262228347 hasConcept C101762097 @default.
- W2262228347 hasConcept C102414288 @default.
- W2262228347 hasConcept C104317684 @default.
- W2262228347 hasConcept C150194340 @default.
- W2262228347 hasConcept C150425827 @default.
- W2262228347 hasConcept C156695909 @default.
- W2262228347 hasConcept C173681060 @default.
- W2262228347 hasConcept C190727270 @default.
- W2262228347 hasConcept C22709980 @default.
- W2262228347 hasConcept C24284526 @default.
- W2262228347 hasConcept C2776745794 @default.
- W2262228347 hasConcept C2780254951 @default.
- W2262228347 hasConcept C2780914512 @default.
- W2262228347 hasConcept C2781376893 @default.
- W2262228347 hasConcept C54355233 @default.
- W2262228347 hasConcept C552990157 @default.
- W2262228347 hasConcept C64927066 @default.
- W2262228347 hasConcept C83640560 @default.
- W2262228347 hasConcept C84772758 @default.
- W2262228347 hasConcept C86339819 @default.
- W2262228347 hasConcept C86803240 @default.
- W2262228347 hasConcept C92477616 @default.
- W2262228347 hasConcept C95444343 @default.
- W2262228347 hasConceptScore W2262228347C10058791 @default.
- W2262228347 hasConceptScore W2262228347C101762097 @default.
- W2262228347 hasConceptScore W2262228347C102414288 @default.
- W2262228347 hasConceptScore W2262228347C104317684 @default.
- W2262228347 hasConceptScore W2262228347C150194340 @default.
- W2262228347 hasConceptScore W2262228347C150425827 @default.
- W2262228347 hasConceptScore W2262228347C156695909 @default.
- W2262228347 hasConceptScore W2262228347C173681060 @default.
- W2262228347 hasConceptScore W2262228347C190727270 @default.
- W2262228347 hasConceptScore W2262228347C22709980 @default.
- W2262228347 hasConceptScore W2262228347C24284526 @default.
- W2262228347 hasConceptScore W2262228347C2776745794 @default.
- W2262228347 hasConceptScore W2262228347C2780254951 @default.
- W2262228347 hasConceptScore W2262228347C2780914512 @default.
- W2262228347 hasConceptScore W2262228347C2781376893 @default.
- W2262228347 hasConceptScore W2262228347C54355233 @default.
- W2262228347 hasConceptScore W2262228347C552990157 @default.
- W2262228347 hasConceptScore W2262228347C64927066 @default.
- W2262228347 hasConceptScore W2262228347C83640560 @default.
- W2262228347 hasConceptScore W2262228347C84772758 @default.
- W2262228347 hasConceptScore W2262228347C86339819 @default.
- W2262228347 hasConceptScore W2262228347C86803240 @default.
- W2262228347 hasConceptScore W2262228347C92477616 @default.
- W2262228347 hasConceptScore W2262228347C95444343 @default.
- W2262228347 hasIssue "S1" @default.
- W2262228347 hasLocation W22622283471 @default.
- W2262228347 hasOpenAccess W2262228347 @default.
- W2262228347 hasPrimaryLocation W22622283471 @default.
- W2262228347 hasRelatedWork W1499797612 @default.
- W2262228347 hasRelatedWork W1919521267 @default.
- W2262228347 hasRelatedWork W1926919861 @default.
- W2262228347 hasRelatedWork W2056228735 @default.
- W2262228347 hasRelatedWork W2068030382 @default.
- W2262228347 hasRelatedWork W2077651882 @default.
- W2262228347 hasRelatedWork W2121264387 @default.
- W2262228347 hasRelatedWork W2170615790 @default.
- W2262228347 hasRelatedWork W2262228347 @default.
- W2262228347 hasRelatedWork W3173225298 @default.
- W2262228347 hasVolume "22" @default.
- W2262228347 isParatext "false" @default.
- W2262228347 isRetracted "false" @default.
- W2262228347 magId "2262228347" @default.
- W2262228347 workType "article" @default.