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- W2262267508 abstract "Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), remains a notorious cause of human death worldwide. A deeper understanding of the proline-glutamate (PE) and proline-proline-glutamate (PPE) families, which compromise 10% of the coding regions in the Mtb genome, has uncovered their unique roles in host-pathogen interactions. Further, comparative genomic analysis of different Mtb strains has proposed that Mtb has acquired diverse gene sets that play immunomodulatory roles in host-pathogen interactions. This review delineates the various immunomodulatory roles of PE/PPE antigens and discusses their implications in the development of the improved diagnostic tools and vaccines." @default.
- W2262267508 created "2016-06-24" @default.
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- W2262267508 date "2015-01-01" @default.
- W2262267508 modified "2023-09-27" @default.
- W2262267508 title "Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features ofMycobacterium tuberculosis" @default.
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- W2262267508 doi "https://doi.org/10.4167/jbv.2015.45.3.272" @default.
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