Matches in SemOpenAlex for { <https://semopenalex.org/work/W2262503792> ?p ?o ?g. }
- W2262503792 endingPage "272" @default.
- W2262503792 startingPage "247" @default.
- W2262503792 abstract "Microglia are brain resident macrophages originated from primitive progenitor cells in the yolk sac. Microglia can be activated within hours and recruited to the lesion site. Traditionally, microglia activation is considered to play a deleterious role in ischemic stroke, as inhibition of microglia activation attenuates ischemia induced brain injury. However, increasing evidence show that microglia activation is critical for attenuating neuronal apoptosis, enhancing neurogenesis, and promoting functional recovery after cerebral ischemia. Differential polarization of microglia could likely explain the biphasic role of microglia in ischemia. We comprehensively reviewed the mechanisms involved in regulating microglia activation and polarization. The latest discoveries of microRNAs in modulating microglia function are discussed. In addition, the interaction between microglia and other cells including neurons, astrocytes, oligodendrocytes, and stem cells were also reviewed. Future therapies targeting microglia may not exclusively aim at suppressing microglia activation, but also at modulating microglia polarization at different stages of ischemic stroke. More work is needed to elucidate the cellular and molecular mechanisms of microglia polarization under ischemic environment. The roles of microRNAs and transplanted stem cells in mediating microglia activation and polarization during brain ischemia also need to be further studied." @default.
- W2262503792 created "2016-06-24" @default.
- W2262503792 creator A5030534238 @default.
- W2262503792 creator A5044042665 @default.
- W2262503792 creator A5073663977 @default.
- W2262503792 creator A5086076274 @default.
- W2262503792 date "2017-10-01" @default.
- W2262503792 modified "2023-10-17" @default.
- W2262503792 title "The biphasic function of microglia in ischemic stroke" @default.
- W2262503792 cites W1483582136 @default.
- W2262503792 cites W1488394086 @default.
- W2262503792 cites W1498166809 @default.
- W2262503792 cites W1523933161 @default.
- W2262503792 cites W1528278198 @default.
- W2262503792 cites W1534989352 @default.
- W2262503792 cites W1545421865 @default.
- W2262503792 cites W1553440385 @default.
- W2262503792 cites W1567490604 @default.
- W2262503792 cites W1575476617 @default.
- W2262503792 cites W1594871287 @default.
- W2262503792 cites W1600123087 @default.
- W2262503792 cites W1606708074 @default.
- W2262503792 cites W1622777525 @default.
- W2262503792 cites W1664596139 @default.
- W2262503792 cites W1670625131 @default.
- W2262503792 cites W1750541493 @default.
- W2262503792 cites W1754402210 @default.
- W2262503792 cites W175813982 @default.
- W2262503792 cites W1847813778 @default.
- W2262503792 cites W1858233563 @default.
- W2262503792 cites W1915908724 @default.
- W2262503792 cites W1932569279 @default.
- W2262503792 cites W1963635405 @default.
- W2262503792 cites W1964041350 @default.
- W2262503792 cites W1964467441 @default.
- W2262503792 cites W1964506812 @default.
- W2262503792 cites W1964680215 @default.
- W2262503792 cites W1967720787 @default.
- W2262503792 cites W1968026156 @default.
- W2262503792 cites W1968537977 @default.
- W2262503792 cites W1969428296 @default.
- W2262503792 cites W1969492143 @default.
- W2262503792 cites W1969949180 @default.
- W2262503792 cites W1970642176 @default.
- W2262503792 cites W1971552578 @default.
- W2262503792 cites W1971820542 @default.
- W2262503792 cites W1971855767 @default.
- W2262503792 cites W1972296893 @default.
- W2262503792 cites W1972442492 @default.
- W2262503792 cites W1972534236 @default.
- W2262503792 cites W1972942987 @default.
- W2262503792 cites W1973393911 @default.
- W2262503792 cites W1973466789 @default.
- W2262503792 cites W1975110303 @default.
- W2262503792 cites W1976010325 @default.
- W2262503792 cites W1976968085 @default.
- W2262503792 cites W1977213877 @default.
- W2262503792 cites W1977838764 @default.
- W2262503792 cites W1978356252 @default.
- W2262503792 cites W1979312949 @default.
- W2262503792 cites W1979938679 @default.
- W2262503792 cites W1979965705 @default.
- W2262503792 cites W1980754289 @default.
- W2262503792 cites W1980775727 @default.
- W2262503792 cites W1981054311 @default.
- W2262503792 cites W1981601043 @default.
- W2262503792 cites W1983393370 @default.
- W2262503792 cites W1984619011 @default.
- W2262503792 cites W1985808298 @default.
- W2262503792 cites W1986489430 @default.
- W2262503792 cites W1987138690 @default.
- W2262503792 cites W1987467507 @default.
- W2262503792 cites W1987547678 @default.
- W2262503792 cites W1987764662 @default.
- W2262503792 cites W1988219883 @default.
- W2262503792 cites W1988536950 @default.
- W2262503792 cites W1989546562 @default.
- W2262503792 cites W1991335610 @default.
- W2262503792 cites W1991805788 @default.
- W2262503792 cites W1992365602 @default.
- W2262503792 cites W1994732314 @default.
- W2262503792 cites W1994781304 @default.
- W2262503792 cites W1995037165 @default.
- W2262503792 cites W1995232831 @default.
- W2262503792 cites W1995776351 @default.
- W2262503792 cites W1997018751 @default.
- W2262503792 cites W1997436944 @default.
- W2262503792 cites W1997713315 @default.
- W2262503792 cites W1998201859 @default.
- W2262503792 cites W1999494818 @default.
- W2262503792 cites W1999952543 @default.
- W2262503792 cites W2001952628 @default.
- W2262503792 cites W2003321649 @default.
- W2262503792 cites W2003410926 @default.
- W2262503792 cites W2003438800 @default.
- W2262503792 cites W2003674452 @default.
- W2262503792 cites W2003813921 @default.
- W2262503792 cites W2004349171 @default.