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- W2262508552 abstract "Objective To study the clinical significance of plasma protein Z(PZ) in patients with hypertensive disorder complicating pregnancy.Methods This cross-sectional study included normal pregnant women(n=60),patients with gestational hypertension(n=30) and patients with pre-eclampsia(PE,n=33,19 mild PE and 14 server PE).The concentrations of maternal plasma PZ were measured by an ELISA method.PZ deficiency was defined as maternal plasma concentrations ≤5 th percentile of the normal pregnancy group(≤1.21 mg /L).Non-parametric statistics and 1-way analysis of variance method(ANOVA) were used for analysis.Results Patients with PE had a lower median plasma concentration of PZ than normal pregnant women(PE:median 1.57 mg /L,range 0.41-3.01 mg /L vs normal pregnancy:median 2.04 mg /L,range 0.64-3.60 mg /L;P0.0001);The median PZ concentrations in patients with gestational hypertension(median 1.80 mg /L,range 0.71-3.51 mg /L) was not significantly different from normal pregnant women(P0.05);Two women with normal pregnancies had a low PZ level(3.3%),compared with 7 patients with gestational hypertension(23.3%) and 15 patients with PE(45.5%).Compared with normal pregnancy,the frequency of decreased PZ was significantly higher in patients with gestational hypertension and in PE(Odds ratio [OR]8.83,95% CI 1.71-45.7,P =0.006 and OR 24.2,95% CI 5.0-115.8,P =0.000,respectively),but no significantly difference was found between patients with gestational hypertension and PE(OR 2.7,95%CI 0.9-8.1,P= 0.057).Conclusion Patients with PE is associated with a significantly lower median level of plasma PZ than normal pregnancy,and a high rate of PZ deficiency is observed in patients with hypertensive disorder complicating pregnancy.It suggested that the decreased PZ may be a risk factor of hypertensive disorder complicating pregnancy." @default.
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- W2262508552 date "2010-01-01" @default.
- W2262508552 modified "2023-09-27" @default.
- W2262508552 title "Clinical Significance of Plasma Protein Z Detection in Patients with Hypertensive Disorder Complicating Pregnancy" @default.
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