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• W2262780705 abstract "AbstractInnate immunity is an important part of immune system, providing immediate defence for the host against various infections through phagocytes. Toll-like receptors (TLRs) are major proteins expressed on the cell membrane known as pattern recognition receptors (PRR) that recognise non-self molecules (pathogen-associated molecular patterns (PAMPs)). Because TLRs have been implicated in many inflammatory diseases and cancer, TLRs targeted therapeutics have drawn great attention in clinical application in wide range of conditions. Many of them are undergoing evaluation in clinical trials. Chitin is the second most abundant polysaccharide detected in many insects and fungi. Studies have shown that chitin, as major PAMPs in host-infection, can activate TLR2-dependent innate immunity pathway. Therefore, chitin has potential use as an important agonist or antagonist to control key processes in innate immunity. However, no direct evidence has shown that chitin is the direct target of TLR2. This study first ..." @default.
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• W2262780705 date "2016-02-02" @default.
• W2262780705 modified "2023-09-22" @default.
• W2262780705 title "Binding mode of chitin and TLR2 via molecular docking and dynamics simulation" @default.
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• W2262780705 doi "https://doi.org/10.1080/08927022.2015.1124102" @default.
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