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- W2262880736 abstract "2-{[(3, 4-Dichlorophenyl) acetyl]amino}-3-methylpentanoic acid (M4) is an enhancer for all-trans retinoic acid (ATRA)-induced differentiation in HL-60 cells. Combination of M4 and ATRA could effectively reduce the useful concentrations of both chemicals and induce complete differentiation. Materials and Methods: The differentiation-inducing activity was measured by NBT-reduction assay, Cell cycle regulation and differentiation-related proteins were detected by Western blotting. Results: combination of M4 and ATRA decreased cyclin D/CDK4 and increased p16 and c/EBPe protein expression to arrest the cells into G0/G1 phase leading to granulocytic maturation. In addition, this differentiation effect is ATRA-dependent pathway mediated by stabilization of RARα. Conclusions: This study provides important information for the development of phenyl-acetic acid (PAA) analogs as differentiation-inducing agents." @default.
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- W2262880736 date "2009-12-01" @default.
- W2262880736 modified "2023-09-23" @default.
- W2262880736 title "2-{[(3,4-Dichlorophenyl) Acetyl] Amino}-3-methylpentanoic Acid (M4) Potentiates ATRA-induced Cell Differentiation in Acute Promyelocytic Leukemia HL-60 Cells" @default.
- W2262880736 doi "https://doi.org/10.7019/tpj.200912.0073" @default.
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