Matches in SemOpenAlex for { <https://semopenalex.org/work/W2262979968> ?p ?o ?g. }
- W2262979968 endingPage "e1005843" @default.
- W2262979968 startingPage "e1005843" @default.
- W2262979968 abstract "Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4), but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and the putative substrate adaptor Mms22 promotes progression of replication forks through damaged DNA. Here we characterized the interactome of Mms22 and found that the Rtt101(Mms22) ligase associates with the replisome progression complex during S-phase via the amino-terminal WD40 domain of Ctf4. Moreover, genetic screening for suppressors of the genotoxic sensitivity of rtt101Δ cells identified a cluster of replication proteins, among them a component of the fork protection complex, Mrc1. In contrast to rtt101Δ and mms22Δ cells, mrc1Δ rtt101Δ and mrc1Δ mms22Δ double mutants complete DNA replication upon replication stress by facilitating the repair/restart of stalled replication forks using a Rad52-dependent mechanism. Our results suggest that the Rtt101(Mms22) E3 ligase does not induce Mrc1 degradation, but specifically counteracts Mrc1's replicative function, possibly by modulating its interaction with the CMG (Cdc45-MCM-GINS) complex at stalled forks." @default.
- W2262979968 created "2016-06-24" @default.
- W2262979968 creator A5009044211 @default.
- W2262979968 creator A5009166103 @default.
- W2262979968 creator A5010763205 @default.
- W2262979968 creator A5011375340 @default.
- W2262979968 creator A5012123542 @default.
- W2262979968 creator A5016911808 @default.
- W2262979968 creator A5043230141 @default.
- W2262979968 creator A5051895232 @default.
- W2262979968 creator A5066800425 @default.
- W2262979968 creator A5073735040 @default.
- W2262979968 creator A5083807284 @default.
- W2262979968 creator A5084914720 @default.
- W2262979968 creator A5090181525 @default.
- W2262979968 date "2016-02-05" @default.
- W2262979968 modified "2023-10-13" @default.
- W2262979968 title "The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress" @default.
- W2262979968 cites W1518829626 @default.
- W2262979968 cites W1564916342 @default.
- W2262979968 cites W1599398129 @default.
- W2262979968 cites W1963512031 @default.
- W2262979968 cites W1975001355 @default.
- W2262979968 cites W1975430247 @default.
- W2262979968 cites W1989831269 @default.
- W2262979968 cites W1994183178 @default.
- W2262979968 cites W1994936934 @default.
- W2262979968 cites W1997389647 @default.
- W2262979968 cites W1997963725 @default.
- W2262979968 cites W2005696404 @default.
- W2262979968 cites W2009851230 @default.
- W2262979968 cites W2013828542 @default.
- W2262979968 cites W2022562381 @default.
- W2262979968 cites W2024072532 @default.
- W2262979968 cites W2039096598 @default.
- W2262979968 cites W2041837518 @default.
- W2262979968 cites W2041859788 @default.
- W2262979968 cites W2051289873 @default.
- W2262979968 cites W2055776712 @default.
- W2262979968 cites W2062741934 @default.
- W2262979968 cites W2066088066 @default.
- W2262979968 cites W2066454074 @default.
- W2262979968 cites W2078740028 @default.
- W2262979968 cites W2079924690 @default.
- W2262979968 cites W2083469733 @default.
- W2262979968 cites W2083942911 @default.
- W2262979968 cites W2084144301 @default.
- W2262979968 cites W2093956580 @default.
- W2262979968 cites W2095004958 @default.
- W2262979968 cites W2096274947 @default.
- W2262979968 cites W2098324291 @default.
- W2262979968 cites W2115383745 @default.
- W2262979968 cites W2119301405 @default.
- W2262979968 cites W2123847083 @default.
- W2262979968 cites W2127073167 @default.
- W2262979968 cites W2127504799 @default.
- W2262979968 cites W2134468416 @default.
- W2262979968 cites W2135565830 @default.
- W2262979968 cites W2137530487 @default.
- W2262979968 cites W2142416165 @default.
- W2262979968 cites W2149888835 @default.
- W2262979968 cites W2151122676 @default.
- W2262979968 cites W2161807953 @default.
- W2262979968 doi "https://doi.org/10.1371/journal.pgen.1005843" @default.
- W2262979968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4743919" @default.
- W2262979968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26849847" @default.
- W2262979968 hasPublicationYear "2016" @default.
- W2262979968 type Work @default.
- W2262979968 sameAs 2262979968 @default.
- W2262979968 citedByCount "30" @default.
- W2262979968 countsByYear W22629799682016 @default.
- W2262979968 countsByYear W22629799682017 @default.
- W2262979968 countsByYear W22629799682018 @default.
- W2262979968 countsByYear W22629799682019 @default.
- W2262979968 countsByYear W22629799682020 @default.
- W2262979968 countsByYear W22629799682021 @default.
- W2262979968 countsByYear W22629799682022 @default.
- W2262979968 countsByYear W22629799682023 @default.
- W2262979968 crossrefType "journal-article" @default.
- W2262979968 hasAuthorship W2262979968A5009044211 @default.
- W2262979968 hasAuthorship W2262979968A5009166103 @default.
- W2262979968 hasAuthorship W2262979968A5010763205 @default.
- W2262979968 hasAuthorship W2262979968A5011375340 @default.
- W2262979968 hasAuthorship W2262979968A5012123542 @default.
- W2262979968 hasAuthorship W2262979968A5016911808 @default.
- W2262979968 hasAuthorship W2262979968A5043230141 @default.
- W2262979968 hasAuthorship W2262979968A5051895232 @default.
- W2262979968 hasAuthorship W2262979968A5066800425 @default.
- W2262979968 hasAuthorship W2262979968A5073735040 @default.
- W2262979968 hasAuthorship W2262979968A5083807284 @default.
- W2262979968 hasAuthorship W2262979968A5084914720 @default.
- W2262979968 hasAuthorship W2262979968A5090181525 @default.
- W2262979968 hasBestOaLocation W22629799681 @default.
- W2262979968 hasConcept C104317684 @default.
- W2262979968 hasConcept C104690221 @default.
- W2262979968 hasConcept C134459356 @default.
- W2262979968 hasConcept C149187182 @default.
- W2262979968 hasConcept C151158763 @default.