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• W2262982604 abstract "4108 Background: Survival after curative surgery for pancreatic adenocarcinoma (PA) is poor and postoperative management is controversial. The identification of prognostic factors may favor interpretation of results from phase II trials, selection of promising therapeutic strategies, and definition of stratification criteria for phase III trials. Methods: A series of 239 patients, curatively resected in a single center for PA between June 1985 and June 2002, was analyzed. The prognostic role of patient- and PA- related variables was estimated by univariate (log-rank test) and multivariate analyses (Cox proportional hazard model), stratifying patients for the year of diagnosis and chemotherapy regimen received. Significance levels were adjusted for multiple group comparisons (Bonferroni method). Results: Post-surgical performance status (PS) >1, stage > IIA, grading > 2, tumor size > 2,9 cm, and pre-surgical CA19.9 value > 5 upper limit of normal were significantly and independently associated with a worse survival (p<0.005), while gender, age, nodal status, resection margins, and site of disease were not. Results were confirmed by the Cox model. Each variable was assigned a value of either 0, if favorable, or 1, if unfavorable. The values were then added together to generate a score and three risk groups were individuated: low, intermediate and high risk for score 0–1, 2–3 and 4–5, respectively. Risk group attribution was possible for 216 (90%) patients due to missing data. Overall survival was significantly different (p<0.0003) across groups: median, 2-yr, and 5-yr overall survival for 55 patients in low-risk group were 28, 58%, and 22%; for 130 patients in intermediate-risk group were 17, 32%, and 6%; and for 31 patients in high-risk group were 9, 10% and 0%. Conclusions: Post-surgical PS, stage, tumor grade and size, and pre-surgical CA19.9 value were independent predictors of survival in patients with PA submitted to curative surgery. A prognostic score including these five variables was able to distinguish three different risk groups with significantly different survival. The proposed risk stratification and its relevance in therapeutic decision deserve to be validated in further studies. No significant financial relationships to disclose." @default.
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• W2262982604 date "2005-06-01" @default.
• W2262982604 modified "2023-10-01" @default.
• W2262982604 title "Resected pancreatic cancer: A proposal for a prognostic score" @default.
• W2262982604 doi "https://doi.org/10.1200/jco.2005.23.16_suppl.4108" @default.
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