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• W2263057803 abstract "The engineering of transcriptional networks presents many challenges due to the inherent uncertainty in the system structure, changing cellular context and stochasticity in the governing dynamics. One approach to address these problems is to design and build systems that can function across a range of conditions; that is they are robust to uncertainty in their constituent components. Here we examine the robustness landscape of transcriptional oscillators, which underlie many important processes such as circadian rhythms and the cell cycle, plus also serve as a model for the engineering of complex and emergent phenomena. The central questions that we address are: Can we build genetic oscillators that are more robust than those already constructed? Can we make genetic oscillators arbitrarily robust? These questions are technically challenging due to the large model and parameter spaces that must be efficiently explored. Here we use a measure of robustness that coincides with the Bayesian model evidence combined with an efficient Monte Carlo method to traverse model space and concentrate on regions of high robustness, which enables the accurate evaluation of the relative structural robustness of gene network models governed by stochastic dynamics. We report the most robust two and three gene oscillator systems, plus examine how the number of interactions, the presence of auto-regulation, and degradation of mRNA and protein affects the frequency, amplitude and robustness of transcriptional oscillators. We also find that there is a limit to parametric robustness, beyond which there is nothing to be gained by adding additional feedback. Importantly, we provide predictions on new oscillator systems that can be constructed to verify the theory and advance design and modelling approaches to systems and synthetic biology." @default.
• W2263057803 created "2016-06-24" @default.
• W2263057803 creator A5031424617 @default.
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• W2263057803 creator A5082148969 @default.
• W2263057803 date "2015-08-20" @default.
• W2263057803 modified "2023-10-18" @default.
• W2263057803 title "A statistical approach reveals designs for the most robust stochastic gene oscillators" @default.
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• W2263057803 cites W1965305472 @default.
• W2263057803 cites W1970768185 @default.
• W2263057803 cites W1974028960 @default.
• W2263057803 cites W1978641328 @default.
• W2263057803 cites W1979833590 @default.
• W2263057803 cites W1981924574 @default.
• W2263057803 cites W1982353649 @default.
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• W2263057803 cites W1993482839 @default.
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• W2263057803 cites W2000641432 @default.
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• W2263057803 doi "https://doi.org/10.1101/025056" @default.
• W2263057803 hasPublicationYear "2015" @default.
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